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Early aggressive fluid resuscitation not better for pancreatitis
Medical Xpress / New England Journal of Medicine ^ | Sept. 16, 2022 | Enrique de-Madaria, M.D., Ph.D. et al

Posted on 09/23/2022 3:36:46 PM PDT by ConservativeMind

Early aggressive fluid resuscitation results in a higher incidence of fluid overload and does not improve clinical outcomes for patients presenting with acute pancreatitis, according to a study.

Enrique de-Madaria, M.D., Ph.D. and colleagues randomly assigned 249 patients at 18 centers who presented with acute pancreatitis to receive goal-directed aggressive or moderate resuscitation with lactated Ringer's solution. Patients were assessed at 12, 24, 48, and 72 hours; fluid resuscitation was adjusted based on the patient's clinical status.

The trial was halted due to between-group differences in the safety outcomes, with no significant difference in the incidence of moderately severe or severe pancreatitis between the groups (22.1 and 17.3 percent in the aggressive- and moderate-resuscitation groups, respectively; adjusted relative risk, 1.30; 95 percent confidence interval, 0.78 to 2.18; P = 0.32). The researchers found that fluid overload developed in 20.5 and 6.3 percent of those who received aggressive and moderate resuscitation, respectively (adjusted relative risk, 2.85; 95 percent confidence interval, 1.36 to 5.94; P = 0.004). The median duration of hospitalization was six and five days in the aggressive- and moderate-resuscitation groups, respectively.

"The use of aggressive fluid resuscitation led to a higher risk of volume overload and did not show the hypothesized benefit in disease-specific outcomes," the authors write.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: pancreatitis
Aggressive use of fluids with acute pancreatitis is dangerous and unnecessary.
1 posted on 09/23/2022 3:36:46 PM PDT by ConservativeMind
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2 posted on 09/23/2022 3:37:24 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

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3 posted on 09/24/2022 5:40:25 AM PDT by sauropod (Unbelief has nothing to say. Chance favors the prepared mind.)
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