Exercise could reduce frailty in the most common form of leukemia (CLL)

Medical Xpress / University of Surrey / Frontiers in Oncology ^ | Sept. 20, 2022 | Andrea Sitlinger et al

[ConservativeMind]

Increased levels of exercise could help reduce frailty in patients with the most common form of leukemia, chronic lymphocytic (CLL), according to new research. The discovery of a link between frailty and "good cholesterol" (high-density lipoprotein (HDL)) could help identify people most at risk.

Researchers found that higher levels of the HDL were directly associated with better physical fitness amongst patients, reducing their risk of frailty. Known factors that increase levels of HDL are a healthy diet and increased physical activity and exercise.

CLL is a type of cancer associated with a decline of major bodily systems, which decreases survival rates due to risks of infection, hospitalizations, and secondary malignancies. Such risks are heightened by low physiological fitness.

Dr. David Bartlett, said:

"Physical decline is more common in those with chronic lymphocytic leukemia compared to any other blood cancer, suggesting that it is the likely cause of such deterioration. Stopping or even slowing down this physical decline will reduce the risk of frailty in a patient and improve their chance of survival.

"It is important that we identify those at risk and give them the support they need; however, until now, we have had no way of knowing this."

It was also found that higher levels of citrate and lower levels of hemoglobin in the blood were more likely to be found in patients with poor physical health.

Researchers also found that patients who had been living with the disease for many years and those who had received treatment had a higher likelihood of low aerobic fitness and function.

Dr. Bartlett added: "High-density lipoprotein removes cholesterol and brings it back to the liver. When its levels are low, cholesterol is utilized by the cancerous cells, increasing the risk of developing a secondary ailment and lowering the chances of survival.

[ConservativeMind]

The HDL importance seems a little unusual, but it is usually an indicator of getting exercise, too.

There are supplements that seem likely to help with CLL, with several being mitophagy supplements. Apparently, CLL cripples mitochondria, and fixing those can curb CLL and some other leukemia conditions.

Urolithin A is one supplement that directly encourages mitophagy.

[ConservativeMind]

Another FReeper sent met this information:

New Leukemia-Killing Compounds Discovered
https://scitechdaily.com/new-leukemia-killing-compounds-discovered/

Mitophagy was key to curbing leukemia.

[ConservativeMind]

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