Exploring the brief use of rapamycin treatment in early adulthood to extend lifespan

Medical Xpress / Max Planck Society / Nature Aging ^ | August 29, 2022 | Linda Partridge et al

[ConservativeMind]

Imagine you could take a medicine that prevents the decline that come with age and keeps you healthy. The current most promising anti-aging drug is rapamycin, known for its positive effects on life and health span in experimental studies with laboratory animals. To obtain the maximum beneficial effects of the drug, it is often given lifelong. However, even at the low doses used in prevention for age-related decline, negative side effects may occur, and it is always desirable to use the lowest effective dose.

A research group has shown in laboratory animals that brief exposure to rapamycin has the same positive effects as lifelong treatment opening new doors for a potential application in humans.

The scientists have tested different time windows of short-term drug administration in fruit flies and found that a brief window of two weeks of rapamycin treatment in young, adult flies protected them against age-related pathology in the intestine and extended their lives. A corresponding short time window, three months of treatment starting at three months of age in young, adult mice, had similar beneficial effects on the health of the intestine when they were middle-aged.

"These brief drug treatments in early adulthood produced just as strong protection as continuous treatment started at the same time. We also found that the rapamycin treatment had the strongest and best effects when given in early life as compared to middle age. When the flies were treated with rapamycin in late life, on the other hand, it had no effects at all. So, the rapamycin memory is activated primarily in early adulthood," explains Dr. Thomas Leech.

"We have found a way to circumvent the need for chronic, long-term rapamycin intake, so it could be more practical to apply in humans," says Dr. Yu-Xuan Lu.

[ConservativeMind]

This is a novel finding. Turn off some aspects of aging before it happens with a small amount of rapamycin, and you don’t need to take it again.

[perfect_rovian_storm]

I’m a pretty experimental kinda guy, but I think I want a TON more info on this before considering it a viable option. :-)

[antidemoncrat]

Like most modern medicines, are side effect worth taking?

Traditional side effects of Rapamycin in transplant patients include:

Hypercholesterolemia
Hypokalemia
Anemia
Thrombocytopenic disorder
Hypertension
Hypertriglyceridemia
Constipation
Kidney disease with reduction in GFR
Urinary tract infection
Acne vulgaris
Arthralgia
Pain
Fever
Skin rash
Peripheral edema
Headache disorder
Nausea
Diarrhea
Acute abdominal pain
Edema

[ChessExpert]

You must be an anti-vaxxer! (Sarcasm)

[reformedliberal]

...you don’t need to take it again.
_________________________________________

Great. Fruit flies that remain juvenile? Immortal fruit flies?

Too late for me and that’s ok.

[ConservativeMind]

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[packagingguy]

I knew I’d heard of this drug from my studies of autism:

Earlier treatment could help reverse autistic-like behavior in tuberous sclerosis

https://www.sciencedaily.com/releases/2018/10/181009155116.htm

Something about mTor (mammalian target of rapamycin) and oxidative stress.

[ConservativeMind]

The good news is that other supplements can, in fact, reverse a reasonable amount of aging issues, even at 80 years of age.

Look up GlyNAC, Urolithin A, and Taurine, on prior threads.

[alancarp]

So how would human trials go? Give the drug to 200 people in their 20’s and then wait for 60+ years to see if it worked? That oughta be comical.

[ConservativeMind]

The lowest dose, used for a few weeks, does not appear likely to cause the issues that chronic users get.

There are definitely issues with longer-term or higher dose use of rapamycin, though.

I know some people have gotten this to help with longevity, due to other studies on it, but I believe there are better options that have no effective side effects, that can help in a similar way.

[reformedliberal]

Yes, thanx. I did see those earlier.

[bk1000]

Revelation 9.6: And in those days shall men seek death, and shall not find it; and shall desire to die, and death shall flee from them.

Just saying

[Parmy]

I am confused. First there are too many people so a virus is invented in a laboratory that need a special vaccine which is designed to kill people.

Now a substance is invented to extend life into real old age.

Which is to be believed? I am confused.

[StolarStorm]

The “elite” want to live forever while the peasants die.

[citizen]

I looked at GlyNAC online. What are your thoughts on the drugs you mentioned?

[ConservativeMind]

My wife and I take GlyNAC, Urolithin A, and Taurine.

[OldWarBaby]

This stuff came from Easter Island, thus the prefix “rapa” as in “Rapa Nui.” It quit working for those folks a thousand or so years ago. And all that’s left is stone heads. I’m in way better shape than all those quacks are so I think I’ll let them go first. Maybe they’ll give me a “heads up” just before their petrification sets in?

[OldWarBaby]

So it’s multiple choice: constipation or diarrhea? pretty shizzy choice, and how much older would one be before those conditions set in? Maybe it’s odds or evens? With all those problems It might just seem like you’re living longer?

[exnavy]

I do not trust pharma enough to try it.

[cicero2k]

I’ll wait for the mouse studies but rapamycin blocks mTOR a known carcinogen pathway; a good thing. However fasting and a low protein diet does similar.