Resistant starch provides lasting benefit in Lynch syndrome (30 grams/day)

Medical Xpress / HealthDay / Cancer Prevention Research ^ | August 18, 2022 | John C. Mathers et al

[ConservativeMind]

For patients with Lynch syndrome (LS), daily resistant starch (RS) seems to have a lasting protective effect against noncolorectal cancers, according to a study.

John C. Mathers, Ph.D., from Newcastle University in the United Kingdom, and colleagues present long-term cancer outcomes based on a planned 10-year follow-up from recruitment in the CAPP2 trial in which participants with LS were randomly assigned to 30 g RS or placebo daily for up to four years. Overall, 463 and 455 participants received RS and placebo, respectively.

The researchers observed no difference in colorectal cancer incidence at up to 20 years of follow-up (52 and 53 patients diagnosed among those assigned to RS versus placebo), but fewer participants had noncolorectal LS cancers among those assigned to RS versus placebo (27 versus 48; intention-to-treat [ITT] analysis hazard ratio, 0.54). The protective effect on RS against noncolorectal cancer LS cancers was confirmed by calculating incidence rate ratios in an ITT analysis allowing for multiple primary cancer diagnoses among participants (incidence rate ratio, 0.52). For cancers of the upper gastrointestinal (GI) tract, these effects were particularly pronounced (five versus 21 diagnoses with RS and placebo, respectively). The ITT analysis showed no effect of RS on colorectal cancer risk. No interaction was seen between aspirin and RS treatment.

"The effect was most obvious in the upper part of the gut," Mathers said in a statement. "This is important as cancers of the upper GI tract are difficult to diagnose and often are not caught early on."

[ConservativeMind]

One in 300 people have the gene for Lynch Syndrome.

Resistant starch is a form of fiber becoming common in low carb/keto foods.

[ConservativeMind]

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[yefragetuwrabrumuy]

Raw potato starch looks like flour and can be blended into smoothies, yoghurt, pudding and unbaked pie filling.

[fella]

I read an article a few weeks ago about resistant starch being good for diabetes. Something about it passing through the small intestine and into the large intestine before being digested.

[logi_cal869]

ROFLMAO

I know what’s coming. Anyone else?

[sauropod]

bkmk

[ckilmer]

resistant starch is any starch that can’t be digested by the juices produced in either the stomach or small intestine.

Rather the starch has to be digested by the bugs in your large intestine and bowels. These bugs produce beneficial short chain fatty acids.

American diets are typically low on resistant starches. So the lower gut does not produce sufficient quantities of short chain fatty acids and whatever else scientists will discover are produced in the lower gut in coming years.

This is a new field of study.