Posted on 06/28/2022 8:38:25 AM PDT by ConservativeMind
The virus that causes COVID-19 undertakes a massive takeover of the body's fat-processing system, creating cellular storehouses of fat that empower the virus to hijack the body's molecular machinery and cause disease.
After scientists discovered the important role of fat for SARS-CoV-2, they used weight-loss drugs and other fat-targeting compounds to try to stop the virus in cell culture. Cut off from its fatty fuel, the virus stopped replicating within 48 hours.
The team embarked on the study based on observations that people with a high body-mass index and conditions like cardiovascular disease and diabetes are more sensitive to the disease.
The team studied the effect of SARS-CoV-2 on more than 400 lipids in two different human cell lines. Scientists found a massive shift in lipid levels, with some fats increasing as much as 64-fold. In one cell line, nearly 80 percent of fats were altered by the virus; in the other, levels of slightly more than half were changed.
The lipids affected most were triglycerides, those little packets of fat that most patients try to keep to a minimum. Triglycerides are crucial for our health, allowing us to store energy and to maintain healthy membranes in our cells.
It turns out that those are also critical for the COVID virus.
When we need energy, cells break up the triglycerides into useful raw material—three fatty acids that each triglyceride molecule contains.
The team found SARS-CoV2 doesn't simply boost the number of triglycerides in our cells. The virus also changes much of our fat-processing system, changing the body's ability to use fat as fuel.
An approved weight-loss medication, Orlistat, a lipase inhibitor, stopped viral replication. An experimental compound known as GSK2194069 also stopped the virus. These and other compounds worked against all the SARS-CoV2 variants tested: alpha, beta, gamma and delta.
(Excerpt) Read more at medicalxpress.com ...
Ping
Was about to post....just imagine what the $hots do 😱
People with higher triglycerides are able to help COVID bloom, creating problems for such persons that others won't get.
Finally, it says a type of drug not previously understood to help served as an antiviral against COVID (Orlistat). It's not too unlike finding out HCQ or Ivermectin can help.
Perhaps that explains why having a high BMI is such an important comorbidity for COVID.
Exactly. Just another off-label use for a drug that can help inhibit the China Virus.
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