Increased fracture risk in patients using insulin compared to metformin

Patients with type 2 diabetes have an increased risk for fractures, despite their normal-to-high bone mineral density, according to research being presented Saturday, June 11 at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.

"Patients using insulin or sulfonylurea are at a high risk of fractures compared to metformin-only users, and the risk could be higher in non-obese and well-controlled diabetic patients," said Sung Hye Kong, M.D., of Seoul National University Bundang Hospital in Seongnam, South Korea.

Kong and colleagues acknowledge that anti-diabetic medications have long been suspected for an increased risk for fractures among this patient population. However, after investigating longitudinal comparative studies, they learned that evidence of these effects are limited.

For their study, the researchers included 6,694 patients aged ≥50 years from the common data model (CDM) database between 2008 and 2011, who used the same anti-diabetic medications for over a year.

They analyzed risks of major osteoporotic fractures and hip fractures in each group using the Cox proportional hazards model compared with a metformin group as a reference.

"From real-world data using the common data model, we found that insulin users were at elevated risk of major osteoporotic and hip fracture compared to metformin users, which was attenuated in users with a combination of insulin and metformin," Kong said.

This increased fracture risk among people who used insulin was exaggerated among people who are not obese and those with well-controlled diabetes. These findings suggest a need for routine fracture risk assessments in patients with diabetes.

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Metformin is a horrible drug.

My first wife (for 47 years) took Metformin for many years and she had constant bowel problems. She died in 2018.

I married again 2 years ago. New wife was using Metformin and same issues. She is on insulin now. It is better.

Diabetes is a horrible disease.

Genetics can play a role, but it's like having a gun with no rounds.

Is type 2 diabetes genetic?

https://www.medicalnewstoday.com/articles/is-type-2-diabetes-genetic#which-genes

If you do have a genetic predisposition, you decide if your body enables it.

For those with or without a genetic flag, it really is what we eat in the way of carbohydrates and how quickly just the carbohydrates are being burned off. Our bodies try to secrete insulin to quickly remove any high blood sugar. When we abuse our bodies for too long, our ability to have insulin divert the blood sugar to muscles (first), then fat cells (second), leaves blood sugar and insulin wandering through our bodies with abandon.

We can directly curb all of our blood sugar response and keep them always healthy, by eating fewer carbs and by ingesting only complex carbs. This is immediately provable with your glucose meter.

People with diabetes can still put it fully into remission by going low carb or Keto. This was never pushed by the ADA, because they believed it to be too difficult for people, but now, that has changed.

The destruction of allowing your blood sugar to stay elevated is enormous, and it degrades all of your organs and blood vessels. This creates numerous other health problems, and even makes you much more likely to have serious problems with an illness like COVID, when it comes your way.

If someone with diabetic genetic issues kept their blood sugar levels lower, they would likely never get diabetes. But how many people do we know who stay active all the time to do that, if eating a lot of carbs? Very few. We are not an agrarian society and we sit too much, now, and when we get older, our bodies don't want to move much to burn anything off, due to pain and cellular issues.

We learn bad eating and exercise habits, which we hold on to for much or all of our lives. This is the most likely reason anyone gets diabetes, regardless of genetic predisposition, or not.

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