Posted on 05/25/2022 2:41:40 PM PDT by ConservativeMind
Reproductive hormone levels in females with obesity may be partially restored by lowering blood glucose levels, leading to improved fertility.
The study indicates that altered levels of reproductive hormones in a well-established mouse model of obesity may be partially restored by a common type 2 diabetes medication that reduces blood glucose levels. Many women with obesity that experience fertility issues also have altered levels of reproductive hormones. Currently there is no effective therapy to address this.
Although fertility problems are well established in women with obesity, there remains a lack of effective and targeted treatments to address them. Obesity-related fertility issues are complex but evidence suggests that, in part, they may be linked to changes in energy metabolism, which lead to altered levels of reproductive hormones that can then disrupt the menstrual cycle and ovulation. People with obesity are at a greater risk of developing type 2 diabetes and often have high blood glucose levels, as well as other metabolic changes.
Dapagliflozin is a drug commonly used to treat type 2 diabetes, where it reduces blood glucose levels and improves other markers of metabolic health but its effects on reproductive health and fertility have yet to be investigated.
In this study, Professor Chen investigated the effects of dapagliflozin treatment on metabolic health and reproductive hormone levels in the MC4R mouse model of obesity. After just eight weeks of treatment blood glucose levels were normal, body weight was reduced, the reproductive cycle was normalized and levels of reproductive hormones and ovulation were partially restored, compared with non-treated mice.
Professor Chen comments that "these data suggest that normalizing blood glucose metabolism with dapagliflozin in obesity may be a promising route for at least partially restoring reproductive function. This could improve fertility in women where no other successful therapy is currently available."
(Excerpt) Read more at medicalxpress.com ...
Might be nature’s way of telling you “you have other problems to worry about before you bring a kid into this world”.
Additionally fat people are not as attractive and thus less likely to get laid.
Earlier today I read that the average waist circumference for an adult American woman is 38 inches. My waist is (just slightly) smaller than that, and I’m a 215 lbs. man. This population is not going to do well with a food shortage. The road to controlling weight and blood sugar goes through the carbs.
The average American woman weighs as much as the average American man did in 1960.
The last time I went to a baseball game made me believe that statistic. We are to the point where a woman can stand apart from the crowd in attractiveness by simply not being really fat.
Compare a high school yearbook in the 60’s or 70’s versus one today. Teenagers are fat today. 90% of the girls in the 70’s would be considered very attractive today.
Women are the heaviest they have ever been.
Fat acts like hormones. Not a surprise they cant have a baby.
You cant have certain surgeries if you are massive. Its too dangerous.
Good obgyn’s tell women having trouble who are obese to lose weight. Its dangerous to be very heavy. Bd obgyn’s refer their fat/obese women patients to fertility specialists who will take their money but not tell them to lose weight, and surprise, they don’t conceive or miscarry.
I needed a little levity injected in my day! Your comment did it! Thanks!
My work here is done. Until next time!
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.