Posted on 05/19/2022 7:31:03 PM PDT by ConservativeMind
One year outcomes from the Disrupt PAD III Trial comparing intravascular lithotripsy (IVL) with a drug-coated balloon (DCB) to percutaneous transluminal angioplasty (PTA) with a DCB was presented today. The results revealed consistent safety and effectiveness of IVL with durable patency.
Impacting approximately 6.5 million Americans over the age of 40, peripheral arterial disease (PAD) is the narrowing of the peripheral arteries that carry blood away from the heart to other parts of the body. PAD is caused by a buildup of fatty plaque in the arteries and treatment options can including lifestyle changes, medical therapy or surgery depending on the severity of the condition. However, patients with severe calcification are often left out of clinical trials.
The Disrupt PAD III study provides the largest randomized controlled evidence to guide endovascular treatment of severely calcified superficial femoral artery-pop lesions.
For IVL or PTA arms, PP follow-up is available in 80.4% and 83.7% of patients, respectively. Primary patency at one-year was significantly greater in the IVL arm (80.5% vs. 68.0%). The per protocol requirement for provisional stenting was significantly lower in the IVL group (4.6% vs 18.3%). Freedom from CD-TLR (IVL: 95.7% vs PTA: 98.3%) and restenosis (IVL: 90.0% vs PTA: 88.8%) were similar between the two groups at 1-year. With IVL, severe complications and the need for additional interventions are reduced compared to PTA.
"This trial offers important new insights because patients with severe PAD are often excluded from trials, resulting in a very limited amount of randomized data to guide treatment," said William A. Gray, M.D., FSCAI. "The trial demonstrated the utility of IVL, rendering these challenging procedures safe and predictable. This offers patients future treatment pathways without the potential long-term risk of adverse clinical events such as stent fracture and restenosis."
(Excerpt) Read more at medicalxpress.com ...
Intravascular lithotripsy (IVL) - A sonic emitter is used within the artery to crack the calcium across the layers of thickness of the artery.
Patency - The state of being open or unobstructed
There are ways to reverse some calcium buildup (High dose Vitamin K and MK4 from one study reversed 50+% of calcium buildup in three months. Additionally, there are ways to reduce a large amount of the soft plaques in our arteries, but both of these take time.
If you are going in for surgery due to a blockage, you don’t have the option to use diet to reverse your problem. In this case, choose IVL for your procedure.
so it breaks off like spawl???
Yup.
wonder what that feels like when a piece runs thru yer brain...
I was wondering about that, too. One of the reasons for using the balloon is that when it inflates it presses the plaque against the artery walls, keeping it in place while it opens up the flow. Seems dangerous to break calcium deposits up and let the pieces run around in the body until they find another spot to plug up.
yup, that and a stent...
📌
bkmk
This procedure is done in the leg arteries. Any embolization that occurs will be only distal (towards the feet). There is no chance of brain embolization. Embolization can and does occur with most endovascular interventions (angioplasty, atherectomy, stenting). We do have a method to prevent embolization, an embolic protection device which is a type of retrievable net that’s placed distal to the intervention.
I take 1k mg of timed release niacin plus 10kiu vitamin d3 k2 mk7 to keep the plaque out of my arteries. I’ve got a little soft plaque build up in my carotids but otherwise they’re clean.
what I wonder is as to whether high dose niacin will give the same increase in NAD+ as NMN or NR. I also take those two but niacin is much cheaper even in high doses.
Sadly I’ve never seen any comparative data as to how well these various forms of b3 build up NAD+
Reminds me of an old joke:
What is the last thing that goes through a bug’s head when it hits the car windshield?
His a$$.
yup...
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