Earlier then that, our first pandemic that we have any knowledge of was during the Neolithic period and was caused by Y. Pestis.
There have been five major pandemics that can be laid at Y. Pestis feet.
20 posted on 05/19/2022 3:39:01 PM PDT by Harmless Teddy Bear
(It is better to light a single flame thrower then curse the darkness. A bunch of them is better yet)