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Experimental Drug Breaks Record For Weight Loss in Latest Clinical Trial Results
https://www.sciencealert.com ^ | May 9, 2022 | PETER DOCKRILL

Posted on 05/09/2022 10:40:21 AM PDT by Red Badger

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To: Crusher138

Whether the reason for obesity is medical or not, once you’re there, you’re there. And at risk for all the (very expensive) maladies that come with it.

It is foolhardy for insurance companies not to cover the great bulk of the cost for those who comply with the diet and exercise regimen. The saved costs from preventing great amounts of obesity related illness would repay the cost of the drug many times over.


21 posted on 05/09/2022 11:29:23 AM PDT by sitetest (Professional patient. No longer mostly dead. Again. It's getting to be a habit. )
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To: pepsi_junkie

Where do I get me some?.......................


22 posted on 05/09/2022 11:39:31 AM PDT by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Secret Agent Man

Don’t forget the other benefits of your advice. Less money spent on food, eating healthier foods, less fat, (obesity has been associated with cardiac disease, certain cancers, less trips to the wrapper, can wear your older clothes(when we were skinnier)....less medicines....win all around..


23 posted on 05/09/2022 11:40:16 AM PDT by Getready (Wisdom is more valuable than gold and diamonds, and harder to find.)
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To: Red Badger

The COVID jabs are effective too. You lose a lot of weight when you die.


24 posted on 05/09/2022 11:46:16 AM PDT by beethovenfan (The REAL Great Reset will be when Jesus returns. )
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To: Crusher138

Have you tried any fasting? I’ve lost 220lbs over the last 5 years by following a low carb diet and fasting 48-120 per week (2-5 days). Yes, I was wearing circus tents, now I’m a curvy XL. I do extended fasts due to my extreme weight and apparently useless metabolism. The results have been pretty astounding, I don’t even have loose skin because the autophagy of long fasts tightens it all up.

My husband lost 50lbs just with the low carb, he hasn’t ever really fasted more than 24 hours. He could stand to lose another 10-15. He’d probably shake them off like dust just doing a single 36 hour fast per week.


25 posted on 05/09/2022 11:53:47 AM PDT by Valpal1 (Not even the police are safe from the police!!!)
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To: Reno89519

http://denverhormonehealth.com/a-beginners-guide-to-aod-9604-weight-loss/


26 posted on 05/09/2022 11:54:31 AM PDT by CTyank
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To: sitetest
"...It is foolhardy for insurance companies not to cover the great bulk..."

I saw what you did there...
27 posted on 05/09/2022 11:55:16 AM PDT by Rebel_Ace (Let's go Brandon!)
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To: Crusher138

I appreciate that losing weight is difficult, but if you are that heavy…not losing weight on 1,000 calories a day…I have to call you on that.

Unless your new doc is an endocrinologist, and they are waiting a paper on you…your numbers don’t work. From a pure physics point of view, moving that much weight throughout a day takes at least 2,400 calories to just maintain. No one’s body is as efficient as you write.


28 posted on 05/09/2022 11:58:54 AM PDT by Vermont Lt
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To: pepsi_junkie

The live tapeworm eggs will do it for sure!!


29 posted on 05/09/2022 12:07:38 PM PDT by Sgt_Schultze (When your business model depends on slave labor, you're always going to need more slaves)
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To: Rebel_Ace

;-)

Wish I could say I did it on purpose. ;-)


30 posted on 05/09/2022 12:11:13 PM PDT by sitetest (Professional patient. No longer mostly dead. Again. It's getting to be a habit. )
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To: shotgun

“Anyone who follows a reduced calorie diet and increase their physical activity will loose weight.”

Wish it was that easy. The drug is used to cut the amount of sugar in the blood. But what do you do with hypoglycemia which already displays low sugar counts, and requires much larger food intakes than Hyper? Insulin resistance comes into focus and there are many times other things that impact exercise and how much can be accomplished. It is more than just pushing yourself away from the table and running a lap.

Also, it has been proven that diabetes is tied into heredity. It can be effected by stress, sleep, and diet, even low carb diets like Atkins or Keto aren’t by themselves the answer to the illness and the other effects from it. People don’t die from diabetes. They are killed by the effects of it like heart attack and stroke.

I read the MSDS for this, and it appears to be like ozempic, a semaglutide injection, a once-weekly noninsulin medicine that along with diet and exercise, may help improve blood sugar in adults with type 2. But it also occasionally passes out the same side effects that may include nausea, vomiting, diarrhea, stomach (abdominal) pain, and constipation. And weight loss is not guaranteed in all patients. Like mentioned above, it is not recommended for all patients either. Wish it was good for all. And diabetes is not a science. It is a daily effort to control a number of problems and side effects so the expectations of most patients can be very different. And very hard to reach in that most.

wy69


31 posted on 05/09/2022 12:11:36 PM PDT by whitney69
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To: Red Badger

Take a look at people on the ‘Carnivore’ diet. Side effects are beneficial as well as the weight loss, ease of following the simple rules, control of appetite, improvement in teeth, gums, skin health, digestive tract happiness, sleep better... Take the 30 day challenge!


32 posted on 05/09/2022 12:22:00 PM PDT by Doctor DNA (Fine words butter no parsnips)
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Comment #33 Removed by Moderator

To: Vermont Lt
I appreciate that losing weight is difficult, but if you are that heavy…not losing weight on 1,000 calories a day…I have to call you on that.

Got it documented. Back when I was 30 I had to go down to 900 calories a day to lose 25 pounds in 6 months. Was on a plan that provided the food - Nutra System - and ate nothing out of the plan. My wife works with me - we are literally a mom and pop shop - and she sees EVERYTHING I eat. I have kept food diaries, weighed and measured everything I ate, I log my exercise. It seems that my burn-calories-by-existing count is in the 500 to 600 calories a day instead of the around 2000 it should be. My body temp is 95 to 96 degrees, all the time. My insurance will not pay for an endocrinologist for "weight loss".

As an aside, I have wicked bad sleep apnea. My CPAP gets me down to 5 to 10 instances per hour, but without it I am over 90 instances per hour. My respiration drops to about 10 to 12 per hour while sleeping, a little low. My apena is a combination of obstructive and central (neurological). When I was on the amphetamine my apena (with CPAP) dropped to about 3 instances per hour. No one can explain it.

34 posted on 05/09/2022 1:10:31 PM PDT by Crusher138 ("Then conquer we must, for our cause it is just")
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To: Red Badger

For Healthcare Professionals
Applies to teriparatide: subcutaneous solution

General
The more commonly reported side effects have included arthralgia, pain, and nausea.

Hypersensitivity
Rare (less than 0.1%): Anaphylaxis, possible allergic events soon after injection (e.g., acute dyspnea, oro/facial edema, generalized urticaria, chest pain, edema (mainly peripheral)

Postmarketing reports: Drug hypersensitivity, angioedema, urticaria[Ref]

Oncologic
Frequency not reported: Osteosarcoma[Ref]

Cases of bone tumor and osteosarcoma have been reported during the postmarketing period; however, an increased risk of osteosarcoma was not observed in observational studies. Two osteosarcoma surveillance safety studies (US claims-based database studies) designed to assess the incidence rate of osteosarcoma showed 3 osteosarcoma cases among 379,283 patients and zero cases among 153,316 patients receiving this drug. A similar risk for osteosarcoma has been observed with comparators. The interpretation of these results suggests caution as data sources do not allow for complete measurement and control for confounders.[Ref]

Genitourinary
Frequency not reported: Urolithiasis

Cardiovascular
Common (1% to 10%): Hypotension, hypertension, palpitations, chest pain, angina pectoris

Uncommon (0.1% to 1%): Tachycardia, cardiac murmur

Frequency not reported: Peripheral edema[Ref]

Gastrointestinal
Common (1% to 10%): Nausea, vomiting, hiatus hernia, gastro-esophageal reflux disease, constipation, diarrhea, dyspepsia, gastrointestinal disorder, tooth disorder

Uncommon (0.1% to 1%): Hemorrhoids[Ref]

Musculoskeletal
Very common (10% or more): Pain in limb, arthralgia (10%)

Common (1% to 10%): Muscle cramps, neck pain, leg cramps

Uncommon (0.1% to 1%): Myalgia, arthralgia, back cramp/pain

Postmarketing reports: Muscle spasms of the leg or back[Ref]

Nervous system
Common (1% to 10%): Dizziness, headache, sciatica, syncope[Ref]

Respiratory
Common (1% to 10%): Dyspnea, rhinitis, cough increased, pharyngitis, pneumonia

Uncommon (0.1% to 1%): Emphysema[Ref]

Dermatologic
Common (1% to 10%): Rash, sweating increased[Ref]

Endocrine
Frequency not reported: Transient hypoparathyroidism[Ref]

Hematologic
Common (1% to 10%): Anemia[Ref]

Local
Common (1% to 10%): Mild and transient injection site events (e.g., pain, swelling, erythema, localized bruising, pruritus, minor bleeding at injection site)

Uncommon (0.1% to 1%): Injection site erythema, injection site reaction[Ref]

Metabolic
Common (1% to 10%): Hypercholesterolemia

Uncommon (0.1% to 1%): Hypercalcemia (greater than 2.76 mmol/L), hyperuricemia, weight gain, alkaline phosphatase increase

Postmarketing reports: Calciphylaxis, worsening of previously stable cutaneous calcification[Ref]

Other
Very common (10% or more): Pain (21%)

Common (1% to 10%): Vertigo, fatigue, asthenia, syncope[Ref]

Psychiatric
Common (1% to 10%): Depression, insomnia[Ref]

Renal
Uncommon (0.1% to 1%): Urinary incontinence, polyuria, micturition urgency, nephrolithiasis

Rare (less than 0.1%): Renal failure/impairment[Ref]

For the Consumer

Applies to teriparatide: subcutaneous solution

Side effects requiring immediate medical attention
Along with its needed effects, teriparatide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking teriparatide:

More common

Confusion
constipation
depression
dry mouth
headache
incoherent speech
increased urination
loss of appetite
metallic taste
muscle weakness
nausea
stomach pain
thirst
unusual tiredness
vomiting
weight loss
Less common

Arm, back, or jaw pain
chest pain, discomfort, tightness, or heaviness
cough
fainting
fast or irregular heartbeat
fever or chills
nausea
sneezing
sore throat
sweating
trouble breathing
Incidence not known

Hives or welts, itching, skin rash
redness of the skin
swelling or puffiness of the mouth and face
Side effects not requiring immediate medical attention
Some side effects of teriparatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach
belching
blurred vision
body aches or pain
diarrhea
difficulty having a bowel movement (stool)
difficulty with moving
dizziness
heartburn
hoarseness
indigestion
lack or loss of strength
muscle pain, stiffness, or spasm
nervousness
pain in the joints
pounding in the ears
runny or stuffy nose
tender, swollen glands in the neck
trouble with swallowing
voice changes
Less common

Back pain
discomfort
discouragement
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
feeling of constant movement of self or surroundings
feeling sad or empty
indigestion
irritability
lack of appetite
leg cramps
loss of interest or pleasure
neck pain
sensation of spinning
sleeplessness
stomach cramps
swollen mouth and tongue
tiredness
tooth disorder
trouble concentrating
trouble sleeping
unpleasant taste
urge to have bowel movement

Incidence not known

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
flushing
unusually warm skin

https://www.drugs.com/sfx/teriparatide-side-effects.html


35 posted on 05/09/2022 1:27:29 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: logi_cal869

Typical long, long list of potential side effects of a drug. Somehow the public was never shown such a list for Covid “vaccines”. Instead scenes with butterflies and fields of daisies advised people to help others by getting the jab.


36 posted on 05/09/2022 1:33:58 PM PDT by Freee-dame
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To: Crusher138

“metabolic issues”


That would be funny if it wasn’t so serious. Fact: Most ‘metabolic issues’ are an effect of lifestyle disease.

One such ‘disease’ was acid reflux.

Those proton pump inhibitors which used to be RX ONLY are now OTC and reeking havoc upon those self-diagnosing themselves.

If this drug remains RX only, I’d be satisfied.

But I seriously doubt that will be the case.


37 posted on 05/09/2022 1:52:04 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: EEGator

Don’t forget the dexedrine.

Then there was Jimmy Buffet’s temporary diet, losing weight without speed eating sunflower seeds, drinking lots of carrot juice and soaking up rays.


38 posted on 05/09/2022 1:58:30 PM PDT by Rebelbase
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To: Red Badger

“Depending on dose, up to one-third of the group on tirzepatide experienced nausea, while diarrhea was also relatively common (for 18.7–23 percent of participants). Some people also experienced vomiting and constipation, although it’s worth noting only a small percentage of participants left the study due to these effects.”

So, the “success” of this drug at helping people lose weight is proportional to the amount of digestive distress it causes.

Would it be surprising to discover that people with digestive distress also ate less as a result?

Unimpressed.


39 posted on 05/09/2022 1:59:05 PM PDT by unlearner (Si vis pacem, para bellum. Let him who desires peace prepare for war.)
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To: Freee-dame
I included everything to avoid bias, but the following is what caught my attention:

Cases of bone tumor and osteosarcoma have been reported during the postmarketing period;...The interpretation of these results suggests caution as data sources do not allow for complete measurement and control for confounders
I'm sure the proclamation will be "Safe & effective".
40 posted on 05/09/2022 2:04:20 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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