Replies

For Healthcare Professionals
Applies to teriparatide: subcutaneous solution

General
The more commonly reported side effects have included arthralgia, pain, and nausea.

Hypersensitivity
Rare (less than 0.1%): Anaphylaxis, possible allergic events soon after injection (e.g., acute dyspnea, oro/facial edema, generalized urticaria, chest pain, edema (mainly peripheral)

Postmarketing reports: Drug hypersensitivity, angioedema, urticaria[Ref]

Oncologic
Frequency not reported: Osteosarcoma[Ref]

Cases of bone tumor and osteosarcoma have been reported during the postmarketing period; however, an increased risk of osteosarcoma was not observed in observational studies. Two osteosarcoma surveillance safety studies (US claims-based database studies) designed to assess the incidence rate of osteosarcoma showed 3 osteosarcoma cases among 379,283 patients and zero cases among 153,316 patients receiving this drug. A similar risk for osteosarcoma has been observed with comparators. The interpretation of these results suggests caution as data sources do not allow for complete measurement and control for confounders.[Ref]

Genitourinary
Frequency not reported: Urolithiasis

Cardiovascular
Common (1% to 10%): Hypotension, hypertension, palpitations, chest pain, angina pectoris

Uncommon (0.1% to 1%): Tachycardia, cardiac murmur

Frequency not reported: Peripheral edema[Ref]

Gastrointestinal
Common (1% to 10%): Nausea, vomiting, hiatus hernia, gastro-esophageal reflux disease, constipation, diarrhea, dyspepsia, gastrointestinal disorder, tooth disorder

Uncommon (0.1% to 1%): Hemorrhoids[Ref]

Musculoskeletal
Very common (10% or more): Pain in limb, arthralgia (10%)

Common (1% to 10%): Muscle cramps, neck pain, leg cramps

Uncommon (0.1% to 1%): Myalgia, arthralgia, back cramp/pain

Postmarketing reports: Muscle spasms of the leg or back[Ref]

Nervous system
Common (1% to 10%): Dizziness, headache, sciatica, syncope[Ref]

Respiratory
Common (1% to 10%): Dyspnea, rhinitis, cough increased, pharyngitis, pneumonia

Uncommon (0.1% to 1%): Emphysema[Ref]

Dermatologic
Common (1% to 10%): Rash, sweating increased[Ref]

Endocrine
Frequency not reported: Transient hypoparathyroidism[Ref]

Hematologic
Common (1% to 10%): Anemia[Ref]

Local
Common (1% to 10%): Mild and transient injection site events (e.g., pain, swelling, erythema, localized bruising, pruritus, minor bleeding at injection site)

Uncommon (0.1% to 1%): Injection site erythema, injection site reaction[Ref]

Metabolic
Common (1% to 10%): Hypercholesterolemia

Uncommon (0.1% to 1%): Hypercalcemia (greater than 2.76 mmol/L), hyperuricemia, weight gain, alkaline phosphatase increase

Postmarketing reports: Calciphylaxis, worsening of previously stable cutaneous calcification[Ref]

Other
Very common (10% or more): Pain (21%)

Common (1% to 10%): Vertigo, fatigue, asthenia, syncope[Ref]

Psychiatric
Common (1% to 10%): Depression, insomnia[Ref]

Renal
Uncommon (0.1% to 1%): Urinary incontinence, polyuria, micturition urgency, nephrolithiasis

Rare (less than 0.1%): Renal failure/impairment[Ref]

For the Consumer

Applies to teriparatide: subcutaneous solution

Side effects requiring immediate medical attention
Along with its needed effects, teriparatide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking teriparatide:

More common

Confusion
constipation
depression
dry mouth
headache
incoherent speech
increased urination
loss of appetite
metallic taste
muscle weakness
nausea
stomach pain
thirst
unusual tiredness
vomiting
weight loss
Less common

Arm, back, or jaw pain
chest pain, discomfort, tightness, or heaviness
cough
fainting
fast or irregular heartbeat
fever or chills
nausea
sneezing
sore throat
sweating
trouble breathing
Incidence not known

Hives or welts, itching, skin rash
redness of the skin
swelling or puffiness of the mouth and face
Side effects not requiring immediate medical attention
Some side effects of teriparatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach
belching
blurred vision
body aches or pain
diarrhea
difficulty having a bowel movement (stool)
difficulty with moving
dizziness
heartburn
hoarseness
indigestion
lack or loss of strength
muscle pain, stiffness, or spasm
nervousness
pain in the joints
pounding in the ears
runny or stuffy nose
tender, swollen glands in the neck
trouble with swallowing
voice changes
Less common

Back pain
discomfort
discouragement
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
feeling of constant movement of self or surroundings
feeling sad or empty
indigestion
irritability
lack of appetite
leg cramps
loss of interest or pleasure
neck pain
sensation of spinning
sleeplessness
stomach cramps
swollen mouth and tongue
tiredness
tooth disorder
trouble concentrating
trouble sleeping
unpleasant taste
urge to have bowel movement

Incidence not known

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
flushing
unusually warm skin

https://www.drugs.com/sfx/teriparatide-side-effects.html