Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

Sodium selenate: A promising treatment for dementia (Selenium from vitamin formulas breaks down tau protein)
Medical Xpress / Monash University / Alzheimer's and Dementia: Translational Research ^ | May 5, 2022 | Lucy E Vivash et al

Posted on 05/05/2022 11:09:35 AM PDT by ConservativeMind

A study has found a promising new treatment for patients with behavioral variant frontotemporal dementia, the second most common form of dementia in the under 60s—resulting in a stabilizing of what would normally be escalating behavioral issues, and a slowing of brain shrinkage due to the disease. It is the second clinical trial to show that the drug, sodium selenate, may slow cognitive decline and neurodegenerative damage that is the hallmark of many dementias including Alzheimer's Disease.

Behavioral variant frontotemporal dementia (bvFTD) is a rapidly progressing destructive disease and can occur in people as young as 35 years of age. It is characterized by behavioral disturbances and personality changes and can be highly disruptive and distressing for both patients and their families. Currently there are no treatments or cures for bvFTD and typical survival is 5–7 years from diagnosis.

The Phase 1 trial run showed that the drug, sodium selenate is safe and well-tolerated in patients with bvFTD over a period of 12 months. Importantly, the majority of patients receiving sodium selenate showed no change in their cognitive or behavioral symptoms, and reduced rates of brain atrophy over the trial period.

In almost half of the cases with bvFTD, the damage to the neurons in the brain is caused by the build-up of a protein called tau.

According to Dr. Vivash, sodium selenate upregulates an enzyme in the brain that effectively breaks down the tau protein. "We have previously shown, in a Phase 2 trial, that sodium selenate given to patients with mild to moderate Alzheimer's Disease resulted in less neurodegeneration than in those who did not," she said. Importantly those patients in the trial with higher levels of selenium, a breakdown product of sodium selenate, in their bloodstream showed less cognitive decline.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: dementia; selenium
Sodium selenate is an inorganic molecule, while other forms are not. It is cheap, but is toxic at low doses beyond normal supplement levels.

The study only used this form, but used actual selenium in the blood as the marker for benefit, so the form used likely doesn’t matter, as any form of selenium would increase blood levels of selenium.

According to ConsumerLab.com, the Upper Tolerable Limit for actual selenium (not a compound) is 400 mcg daily. There’s no likely need to go above that, and I routinely get about half that from my supplements.

1 posted on 05/05/2022 11:09:35 AM PDT by ConservativeMind
[ Post Reply | Private Reply | View Replies]

To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Now keeping a new list (“Common/Top Issues”) for conditions expected to only concern at least 1% of the population. Ask to be on either the “Common/Top Issues” or “Everything” list.

Please email or private message me if you want on or off of a list and of which list you desire.

2 posted on 05/05/2022 11:10:17 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

Put it in the White House water supply


3 posted on 05/05/2022 11:13:31 AM PDT by PGR88
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

So does this suggest we should eat more Brazil nuts (which are high in Selenium)?


4 posted on 05/05/2022 11:13:34 AM PDT by plsvn
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

Two Brazil nuts a day.


5 posted on 05/05/2022 11:14:26 AM PDT by kiryandil (China Joe and Paycheck Hunter - the Chink in America's defenses)
[ Post Reply | Private Reply | To 1 | View Replies]

To: kiryandil; plsvn

I’ve read that the actual amount of selenium in a Brazil nut can vary by 10-fold, so it’s not the most reliable approach for a consistent amount.


6 posted on 05/05/2022 11:17:00 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
[ Post Reply | Private Reply | To 5 | View Replies]

To: PGR88

Bidet&Co need an IV Drip, right into the neck aorta.


7 posted on 05/05/2022 11:21:34 AM PDT by Carriage Hill (A society grows great when old men plant trees, in whose shade they know they will never sit.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: ConservativeMind
good point.

I do two a day, plus the supplement in the cr@p multivitamin.

8 posted on 05/05/2022 11:25:56 AM PDT by kiryandil (China Joe and Paycheck Hunter - the Chink in America's defenses)
[ Post Reply | Private Reply | To 6 | View Replies]

To: ConservativeMind

Because a cardiologist has ALL his patients take CoQ10 and selenium daily I added selenium to mine since I have been taking CoQ10 for years already.

But I did not want *another* supplement. So I buy 2 pound bags of Brazil nuts and eat one nut every day. That is about 97mcg *per nut*. This is cheaper and easier than buying another supplement.


9 posted on 05/05/2022 11:26:37 AM PDT by ChildOfThe60s ( If you can remember the 60s.....you weren't really there..)
[ Post Reply | Private Reply | To 1 | View Replies]

To: ConservativeMind

Is it just me...or is he posting a lot of dementia articles!


10 posted on 05/05/2022 11:27:43 AM PDT by sanjuanbob
[ Post Reply | Private Reply | To 1 | View Replies]

Is that shipped to the WH on pallets by Amazon Pantry?


11 posted on 05/05/2022 11:58:43 AM PDT by TnTnTn
[ Post Reply | Private Reply | To 3 | View Replies]

To: sanjuanbob

I forget.


12 posted on 05/05/2022 3:24:10 PM PDT by BozoTexino (RIP GOP)
[ Post Reply | Private Reply | To 10 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson