[ConservativeMind]

From the write up at the link:

“It turned out that 1 out of 1500 had inherited the gene defect from both parents and were therefore extremely susceptible to viral infections and vaccines with live viruses such as the MMR vaccine.”

Those with one copy make up 2.4% - 3.4% of the Inuit population. I got that from the actual study. To put it back into your desired example, that means up to “ONE in TWENTY-NINE.”

I can't put everything in a 300 word excerpt.

[FarCenter]

From the remaining 4,619 Greenlandic individuals, we identified 220 heterozygous and three homozygous carriers yielding an overall MAF of 0.024 (imputation confidence 0.987). To assess the distribution of the p.Ser53Pro variant, we performed a local ancestry analysis where the phased haplotypes for each individual are colored according to their European or Inuit ancestry. The p.Ser53Pro allele was exclusively found on a background of Inuit ancestry, whereas the reference allele was identified on both European and Inuit backgrounds (Fig. 1 D). Ancestry-specific allele frequencies were 0.034 and 0.000 for the Inuit and European ancestries, respectively. Consistent with these findings, we undertook a separate analysis of a published WES dataset from 104 healthy individuals of Inuit heritage from Nunavik, Canada (Zhou et al., 2019). The p.Ser53Pro allele was present in the heterozygous state in seven individuals (MAF 0.034). Excluding related individuals (defined as second degree or closer) gave a slightly higher MAF of 0.047. Collectively, these data indicated that the p.Ser53Pro IFNAR2 variant was present at a relatively high allele frequency in association with Inuit ancestry.

The numbers are pretty small for good statistical accuracy. There is no information about the relatedness of the individuals carrying the allele. The geographic scope is small compared with the area occupied by Inuit.

Likely such a defect could arise and persist in the population because contacts between Inuit were so infrequent that viral disease epidemics were rare. Natural social distancing due to geography.

[alexander_busek]

“It turned out that 1 out of 1500 had inherited the gene defect from both parents and were therefore extremely susceptible to viral infections and vaccines with live viruses such as the MMR vaccine.”

Those with one copy make up 2.4% - 3.4% of the Inuit population. I got that from the actual study. To put it back into your desired example, that means up to “ONE in TWENTY-NINE.”

Since the trait is recessive, only 1 in 1500 will have anything to worry about.

I can't put everything in a 300 word excerpt.

Researchers discover serious gene defect in 1 in 1500 Inuits populations

There! Shorter - but more informative.

Regards,