Helping pre-term babies avoid bronchopulmonary dysplasia by controlling immune responses (Hep B vaccine is dangerous for encouraging type-2-polarized inflammation)

Medical researchers are closer to understanding the inflammatory responses in pre-term babies that can cause devastating heart and lung conditions including bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH).

It is the immune system's job to defend the body from harmful invaders. Because there is a myriad of pathogens, stunningly versatile defense strategies have evolved, including one called type-2-polarized inflammation.

Type-2-polarized inflammation's regular job is to fight off parasites and counterbalance type-1 and -3 responses. However, in babies with under-developed lungs, this inflammatory response is out of place and out of control, and can cause permanent damage to lung tissue, its supplying blood vessels and the heart.

Professor Marcel Nold says the research is significant: "The discovery that type-2-polarized inflammation drives cardiopulmonary disease in these babies allows us to now work on ways to control it and avoid the damage it wreaks."

"We have also managed to identify that administering the hepatitis B vaccine shortly after birth—as is done in a number of neonatal intensive care units—can augment type-2-driven inflammation, but delaying this vaccine can avoid that problem," Prof Nold said.

"There is nothing wrong with the hepatitis B vaccine itself," he said. Simply giving the vaccine later will likely do the trick for most babies."

Fellow researcher, Professor Claudia Nold, says this research has also provided insight into how some existing treatments work: "We have known that administration of magnesium sulfate and glucocorticoids to the mother before birth have protective properties in preterm infants, and our research now identifies a mechanism by which this protection works."

The team also believes there could be new treatment strategies to tackle early life cardiopulmonary disease. It has been known for some time that type-2-polarized inflammation also plays a critical role in diseases affecting older children and adults, for example in asthma and allergies.

About the Hep B vaccine, all babies normally get the first Hep B vaccine in the first hours of life. This is for a disease that you can only get as follows (courtesy of HealthyChildren.org):

- During birth (if the mother has HBV)

- Sharing personal items, such as razors or toothbrushes, with a person who is infected

- Having unprotected sex with a person who is infected

- Injecting or shooting drugs using a needle with infected blood -- Infection through direct contact with infected blood may occur.

- Some children may also become infected with HBV while living in the same household as a person with a lifelong form of the infection.

If the baby will be in an environment in which he or she will have unprotected sex (but only a problem with an infected person), do drugs with someone (but only a problem with an infected person), or live with a family member that might share some infectable bodily fluids, your baby will not be able to contract Hep B, so there should be no fear around NOT getting the Hep B vaccine at birth.

I personally got the Hep B vaccine in my 30s, and it was just on a whim. One out of every 279 people in the US has this disease, with a much higher amount among illegals.

I encourage an alternate vaccine schedule (Dr. Sears) and consideration of not doing Hep B until rather older.

I realize what I say above is a bit audacious, but the Medical Establishment pushes the Hep B vaccine as the very first vaccine for all humankind, yet, it is only a remote concern, at best. As long as medical staff and family members do not both have Hep B AND do the disgusting, illegal behavior with your baby, your baby is not at risk.

But, you never know, apparently, and that’s why your baby gets that vaccine, before their first day of breathing air is over.

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