Posted on 04/02/2022 3:51:43 PM PDT by ConservativeMind
Obese mice that were fed a high-fat diet and that received prednisone one time per week had improved exercise endurance, got stronger, increased their lean body mass and lost weight, reports a new study. The mice also had increased muscle metabolism.
The once-weekly prednisone promoted nutrient uptake into the muscles.
Investigators also found these mice had increased adiponectin levels, a fat-derived hormone that appears to play an important role in protecting against diabetes and insulin resistance.
The scientists also showed mice that were already obese from eating a high-fat diet also had benefit after once-weekly prednisone, experiencing increased strength, running capacity and lower blood glucose.
"Daily prednisone is known to promote obesity and even metabolic syndrome—a disorder with elevated blood lipids and blood sugar and weight gain," McNally said. "So, these results, in which we intermittently 'pulse' the animals with once-weekly prednisone, are strikingly different."
In previously published research, McNally's team discovered giving prednisone intermittently was helpful for muscular dystrophy.
The benefits of weekly prednisone are linked to circadian rhythms, reports another new study from Northwestern and University of Cincinnati published last month in Science Advances.
Human cortisol and steroid levels spike early in the morning before you wake up.
"If you don't give the drug at the right time of day, you don't get the response," Quattrocelli said. "In mice, we obtained good effects with intermittent prednisone in muscle mass and function when we dose them at the beginning of their daytime. Mice have a circadian rhythm inverted to us, as they generally sleep during the daytime and are active at night. This could mean that the optimal dosing time for humans during the day could be in the late afternoon/early evening, but this needs to be appropriately tested."
(Excerpt) Read more at medicalxpress.com ...
Prednisone can also permanently turn your teeth a bright shade of yellow, like canary yellow, and cause skin problems if you go in the sunshine while taking a course of it.
Isn’t it a steroid? You might end up slapping your host right before your award.
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