Could diet modification make chemotherapy drugs more effective for patients with pancreatic cancer? (Keto both stresses and starves cancer cells)

Medical Xpress / The Translational Genomics Research Institute / Med ^ | Mar. 21, 2022 | Steve Yozwiak / Lifeng Yang et al

[ConservativeMind]

The findings of a new study suggest that a ketogenic diet—which is low in carbohydrates and protein, but high in fat—helps to kill pancreatic cancer cells when combined with a triple-drug therapy.

In laboratory experiments, the ketogenic diet decreased glucose (sugar) levels in the tumor, suggesting the diet helped starve the cancer. In addition, this diet elevated ketone bodies produced by the liver, which put additional stress on the cancer cells.

By destabilizing the cancer cells, the ketogenic diet created a microenvironment in which the triple-drug therapy designed by TGen—a combination of gemcitabine, nab-paclitaxel and cisplatin—was more effective at knocking out the tumor, according to the study.

"By limiting glucose availability, the ketogenic diet may promote chemotherapy efficacy," said Professor Daniel D. Von Hoff, M.D., considered one of the nation's foremost authorities on pancreatic cancer.

In addition, the ketogenic diet was shown to have a favorable impact on antitumor immunity by inducing pro-inflammatory tumor gene expression, which further weakened the cancer.

Clinical trials at five locations

To test these laboratory findings, researchers initiated a clinical trial of up to 40 patients at five centers nationwide: Scottsdale, Los Angeles, Connecticut, New Jersey, and San Antonio.

The clinical trial will test whether adding a ketogenic diet to the triple-drug therapy will increase overall survival in patients with pancreatic cancer. This clinical trial began in late 2020 and is anticipated to continue to accrue patients through June 2023. Patients will be randomly assigned to either receive the triple-drug regimen while on a standard diet, while the other half will receive a ketogenic diet and the triple-drug therapy.

"Our laboratory experiments show that a ketogenic diet changes pancreatic cancer metabolism and its response to chemotherapy," said Haiyong Han, Ph.D., and one of the study authors and a designer of the study's experiments.

[Delta 21]

We never should have trusted them in the 1st place. They used to advertise cigarettes the same way they do opioids and anti-depressants now.

[JohnnyP]

If it shows up on a PET scan it’s eating glucose. It’s unsettling it’s unsettled.

I think low carb extended the life of my wife about six months. The standard prognosis was 18 to 24 months, she lasted 30 months.

She wasn’t as low carb as I wanted her to be, but her glucose was in the 90’s, ketones always over 2.0.

She had a lump in her breast removed in 2013, then it came back in her spine. She thought the pain was old age, etc so she let it go way too long.

We tried 50 sessions of hyperbaric oxygen therapy. She felt better but it still progressed.

[alternatives?]

Good point.

[dennisw]

Here is some research that says that plain old cheaper niacin will boost NAD levels. Therefore, I would think to fight cancer or act to prevent it
https://www.lifespan.io/news/niacin-increases-nad-significantly-in-human-trial/

++++ My guess would be the niacin that gives you a flush is what they are talking about.

[dennisw]

“Until recently, sugar was considered an expensive spice, imported from afar by adventurous traders, not a primary fuel source.”

Panela is 100% whole sugar from Colombia. It comes in hard brown block you can buy in a Hispanic store. You must chip away at the block with a knife to free up the sugar you want to use. Panela is made by boiling down sugar cane juice. I have some in my cupboard.

https://www.youtube.com/watch?v=1K6XKadWWq8

[Grampa Dave]

A little 4 years ago, 3 friends were diagnosed with this terrible cancer.

One went on the standard cancer drug protocols and died miserably about 2 years post.

One went on the UC/K protocols, and she is in remission and doing well.

One via Mayo’s went on the Keto and cancer drug protocols, he beat the odds. Recently, he was diagnosed with CA of the prostrate walls. They kept him on the Keto and did some other. He seems to be still in remission for his pancreatic Ca and is doing fine with the new UC protocol.

[ConservativeMind]

That is the kind of insightful background that really makes these threads useful to me.

Thank you.

[BobL]

Thanks Gramps, I have a feeling they’re finally starting to figure it out. Perhaps the word can get out while drug companies are drowning in ‘vaccine’ profits (they may not notice).

[FrogMom]

What are UC/K protocols, please?