Ketone bodies reduce markers of asthma in obese mice (Non keto diet worked, too, with ketone supplement)

Medical Xpress / American Physiological Society / American Journal of Physiology-Lung Cellular ^ | Feb. 28, 2022 | Madeleine M. Mank et al

[ConservativeMind]

More than half of people with asthma are obese. These individuals do not respond well to standard therapies, but new research holds promise for improving asthma treatments for this population.

"Our results provide innovative first steps toward a safe, efficacious and cost-effective strategy that may uniquely target obese asthma," the researchers wrote.

In addition to responding poorly to standard therapies, people with obesity and asthma are hospitalized at higher rates. Weight loss is a typical recommendation to ameliorate the effects of obesity on asthma. However, short of surgical intervention, only about 15% of people can sustain 10% weight loss for an entire year through diet changes. Even fewer can sustain weight loss for five years.

The research team set out to explore if ketone bodies, which are products of fat metabolism generated by the liver during weight loss, could provide relief from asthma symptoms. They used both genetic and diet-induced mouse models of obesity. They induced the natural generation of ketone bodies through a ketogenic diet in some mice and, in others, through rapid weight loss from a low-fat diet. Other cohorts were given supplementary ketone esters either long term in their food or in acute doses immediately before testing.

In all these models and methods of intervention, the mice with ketone bodies in their system showed less sensitivity to a trigger of airway constriction commonly used in the diagnosis of asthma. The authors note that ketone ester supplementation is considered safe and is already used in some human populations.

"This ketone ester supplementation strategy could be optimized as an approach to promote a state of 'therapeutic ketosis' similar to that achieved through the feeding of a ketogenic diet or fasting, without any caloric deficit or the need for substantial lifestyle modification," the authors wrote.

[ConservativeMind]

Keto esters are available as a supplement at health food stores and online, if a keto diet is not to your liking. Both give enough ketone benefit to curb roughly 10-20% of the attacks, it appears from the study.

Additionally, if you lose the weight, the more conventional medicines will work much better for you, again, from the study.

It’s a “win-win.”

[ConservativeMind]

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[metmom]

"Our results provide innovative first steps toward a safe, efficacious and cost-effective strategy that may uniquely target obese asthma," the researchers wrote.

I guess it is easier to take a pill than to make better lifestyle choices.

If the health benefits are not enough motivation for someone who is obese to lose weight,…… I guess there is just not much you can do for them.