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Ivermectin, ‘Wonder drug’ from Japan: the human use perspective
NIH and Proc Jpn Acad Ser B Phys Biol Sci. 2011 Feb 10; 87 ^ | 2011 Feb 10; 87 | Andy CRUMP*1 and Satoshi ŌMURA*1†

Posted on 02/26/2022 4:21:42 PM PST by dennisw

Abstract Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil—has had an immeasurably beneficial impact in improving the lives and welfare of billions of people throughout the world. Originally introduced as a veterinary drug, it kills a wide range of internal and external parasites in commercial livestock and companion animals.

It was quickly discovered to be ideal in combating two of the world’s most devastating and disfiguring diseases which have plagued the world’s poor throughout the tropics for centuries. It is now being used free-of-charge as the sole tool in campaigns to eliminate both diseases globally. It has also been used to successfully overcome several other human diseases and new uses for it are continually being found. This paper looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a “wonder” drug.

Keywords: avermectin, ivermectin, mode of action, onchocerciasis, lymphatic filariasis, drug resistance Go to: Introduction There are few drugs that can seriously lay claim to the title of ‘Wonder drug’, penicillin and aspirin being two that have perhaps had greatest beneficial impact on the health and wellbeing of Mankind. But ivermectin can also be considered alongside those worthy contenders, based on its versatility, safety and the beneficial impact that it has had, and continues to have, worldwide—especially on hundreds of millions of the world’s poorest people. Several extensive reports, including reviews authored by us, have been published detailing the events behind the discovery, development and commercialization of the avermectins and ivermectin (22,23-dihydroavermectin B), as well as the donation of ivermectin and its use in combating Onchocerciasis and lymphatic filariasis.1–6) However, none have concentrated in detail on the interacting sequence of events involved in the passage of the drug into human use.

When it first appeared in the late-1970s, ivermectin, a derivative of avermectin (Fig. ​(Fig.1 )1 ) was a truly revolutionary drug, unprecedented in many ways. It was the world’s first endectocide, forerunner of a completely new class of antiparasitic agents, potently active against a wide range of internal and external nematodes and arthropods. In the early-1970s, a novel international Public Sector–Private Sector partnership was initiated by one of us (Ōmura, then head of the Antibiotics Research Group at Tokyo’s Kitasato Institute), forming a collaboration with the US-based Merck, Sharp and Dohme (MSD) pharmaceutical company. Under the terms of the research agreement, researchers at the Kitasato Institute isolated organisms from soil samples and carried out preliminary in vitro evaluation of their bioactivity. Promising bioactive samples were then sent to the MSD laboratories for further in vivo testing where a potent and promising novel bioactivity was found, subsequently identified as being caused by a new compound, which was named ‘avermectin’.7) Despite decades of searching around the world, the Japanese microorganism remains the only source of avermectin ever found.1) Originating from a single Japanese soil sample and the outcome of the innovative, international collaborative research partnership to find new antiparasitics, the extremely safe and more effective avermectin derivative, ivermectin, was initially introduced as a commercial product for Animal Health in 1981.

It is effective against a wide range of parasites, including gastrointestinal roundworms, lungworms, mites, lice and hornflies.7–12) Ivermectin is also highly effective against ticks, for example, the ixodid tick Rhipicephalus (Boophilus) microplus, one of the most important cattle parasites in the tropics and subtropics, which causes enormous economic damage. Indicative of the impact, in Brazil, where some 80% of the bovine herd is infested, losses total about $2 billion annually.13) Today, ivermectin is being used to treat billions of livestock and pets around the world, helping to boost production of food and leather products, as well as keep billions of companion animals, particularly dogs and horses, healthy. The ‘Blockbuster’ drug in the Animal Health sector,

EXCERPT


TOPICS: Agriculture; Business/Economy; Conspiracy
KEYWORDS: ivermectin; japan; japanstudy; nih
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1 posted on 02/26/2022 4:21:42 PM PST by dennisw
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Ivermectin is banned due to its chronic unprofitability to cronies


2 posted on 02/26/2022 4:24:51 PM PST by dsrtsage ( Complexity is just simple lacking imagination)
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To: dennisw
But … but … but … Orange Man Bad.

3 posted on 02/26/2022 4:25:32 PM PST by Governor Dinwiddie (LORD, grant thy people grace to withstand the temptations of the world, the flesh, and the devil.)
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To: dennisw

The dirty little secret they’ve been hiding all this time is that all of these dewormer medications are also potent against a wide variety of cancers, with none of the toxicity. But being generics (taking away big pharma’s obscene profits) this info is kept on the downlow. Go ahead and check out pubmed or google scholar and type in any one from this class of drugs + cancer and you can see all of the studies yourself. It isn’t just covid treatments they’ve been jerking us around with.


4 posted on 02/26/2022 4:30:07 PM PST by jimwatx
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To: dennisw

It works on animals, so it can’t possibly work with humans. That would mean Trump is right, and we can’t have that.


5 posted on 02/26/2022 4:30:42 PM PST by Telepathic Intruder (Democracy is two dead Democrats and a Republican voting who's brains are for dinner.)
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To: jimwatx

Was just about to post similar.

THIS is why they don’t want the masses taking it.


6 posted on 02/26/2022 4:32:30 PM PST by Jane Long (What we were told was a “conspiracy theory” in 2020 is now fact. 🙏🏻 Ps 33:12)
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To: dadgum

Ivermectin *PING*


7 posted on 02/26/2022 4:45:55 PM PST by dadgum (Overjoyed to be the Pariah.)
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To: jimwatx

You are thinking about FenBen aka Fenbendazole. What Joe Tippen took for lung cancer. Also sold as dog dewormer called Panacur at Amazon etc —— But I agree that HCQ and Ivermectin most likely work against cancer because they stimulate liver detoxification. But me sneaking suspicion is that Fenben is the best of the three. Take the powder with some olive oil or DMSO

https://www.amazon.com/s?k=fenben+lab&crid=30GOX9TM3HNV9&sprefix=fenben+lab%2Caps%2C84&ref=nb_sb_noss

https://www.ebay.com/itm/154813495973?hash=item240b9a7aa5:g:rSoAAOSwob5hykWB

https://www.connersclinic.com/is-joe-tippens-still-alive-2021-update-fenbendazole-anti-cancer-drug-treatment/


8 posted on 02/26/2022 5:08:06 PM PST by dennisw
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To: jimwatx

On cancers my guess is FenBen is number one. Then Ivermectin. Then HCQ.

The big Lupus Doc in LA with 4000 patients used HCQ on them. Read this on Lupus. Lupus is an autoimmune disease. >>>> https://www.mayoclinic.org/diseases-conditions/lupus/symptoms-causes/syc-20365789


9 posted on 02/26/2022 5:15:44 PM PST by dennisw
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To: dennisw
Director of the Nagao Clinic Dr. Nagao speaks on Ivermectin

Meanwhile, in America...


10 posted on 02/26/2022 5:18:44 PM PST by \/\/ayne (I regret that I have but one subscription cancellation notice to give to my local newspaper)
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To: dennisw

I’m aware of fenbendazole and Joe Tippen, and that’s fine since that particular anthelmintic is readily available as dog dewormer, but every drug in that class appears to be potent against cancer as well. Albendazole seems to be the best.

https://duckduckgo.com/?q=albendazole+%2Bcancer&atb=v1-1&ia=web


11 posted on 02/26/2022 5:20:06 PM PST by jimwatx
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To: dennisw

In sum, Ivermectin has become the victim of Big Pharma and the Progressive Maoist/DSA Democrat Left.
This ‘wonder’ drug presently conflicts with their need to create fear and their power.


12 posted on 02/26/2022 5:33:33 PM PST by Doc91678 (Doc91678)
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To: Telepathic Intruder

As I understand it, it was developed for humans. Its benefits for animals were discovered later.

I had the covid recently. Low-grade fever with chills, a little runny nose, and tired as hell. I could sleep like a teenager. It was nice in a way, forced time off work and sleeping all the time.

Worst of it lasted about three days, with two more days getting back to normal. I came out of it feeling rested and ready, just from all the extra sleep I got.

I have a bunch of the “horse paste” on hand and have for a while, but I didn’t touch it, because I’ve been far sicker, long before Fauci and the Chinese invented covid.


13 posted on 02/26/2022 5:57:12 PM PST by NorthWoody (Half of all people are below average, and half of those are in the bottom 25%.)
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To: dennisw

for later


14 posted on 02/26/2022 6:00:32 PM PST by politicianslie (Those who got vaxxed need to update their wills. You are a test guinea pig & Just starting test!)
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To: jimwatx

Thanks I will look at the DDG links...


15 posted on 02/26/2022 6:07:55 PM PST by dennisw
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bkmk


16 posted on 02/26/2022 6:41:36 PM PST by Faith65 (Isaiah 40:31 )
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To: dennisw

Bought mine online from Singapore. No prescription. 10 days to get it. 100 tablets. $80.00 + $40.00 shipping.

Quercetin, D3, C, zinc, Lysine, Xlear nasal spray, + other supplements every day.

Ivermectin on hand in case myself or the wife need it. No need to wait. No need of a doctor telling me I can’t have it, no need of a pharmacist telling me they won’t fill a legal prescription should I get one.


17 posted on 02/26/2022 6:51:34 PM PST by faucetman (Just the facts, ma'am, Just the facts )
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To: dennisw

Bookmark


18 posted on 02/26/2022 8:01:08 PM PST by Glinda Whatsit
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To: dsrtsage

Eqvalan equine dewormer paste , manufactured by Merck, has been discontinued by the manufacturer.


19 posted on 02/26/2022 8:15:45 PM PST by drSteve78 (Je suis Deplorable STILL)
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To: dennisw
...looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a “wonder” drug.

Impossible! The CDC told us it's horse paste and we are not horses. CDC Knows Best.

20 posted on 02/26/2022 8:16:30 PM PST by ProtectOurFreedom (If truckers quit their jobs, society would collapse. If politicians quit their jobs...HALLELUJAH!)
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