Herbs that protect the heart: Study shows bilobalide reduces cardiac damage in myocardial ischemia (Ginkgo biloba extract)

Medical Xpress / Cactus Communications / Journal of Pharmaceutical Analysis ^ | Feb 24, 2022 | Zhe Wang et al

[ConservativeMind]

The normal functioning of human body requires a steady flow of energy. This energy in the form of adenosine triphosphate (ATP) is produced by breaking down carbon sources like glucose, lipids, or amino acids. The tricarboxylic acid (TCA) cycle, one of the most important ATP-producing processes in the mitochondria, is a major hub of metabolites and is known for ensuring a fine balance between its cyclic intermediates, referred to as the 'metabolic flux.' There is a general consensus that this metabolic flux is impaired in heart-related disorders. A common example is myocardial ischemia (MI), a condition in which blood flow to the heart is reduced, preventing the heart muscles, or cardiomyocytes, from receiving enough oxygen. While it is well understood that MI is marked by decreased ATP synthesis and increased glucose breakdown, or "glycolysis," manipulating the complex TCA cycle to develop treatment options is extremely difficult.

In the past, Ginkgo biloba L. extract (GBE), which contains the active component bilobalide, has been used as a popular herbal medicine in the treatment of ischemic heart diseases. However, the exact mechanism through which it exerts anti-ischemic effects is still unknown.

Interestingly, on treating the injured cells with GBE, the authors found that the active ingredient bilobalide could protect the mitochondria and preserve ATP generation. The enzyme levels in the treated cells went down and prevented metabolite accumulation, enhanced metabolic flux, and reduced the pressure on heart cells. The modulation of metabolic flux in GBE treated cells works by lowering accumulation of TCA cycle intermediates, which is different from previously reported mechanisms.

Testing the efficacy of bilobalide in a rat model of MI yielded similar results. The findings were consistent with those of the ISO-injured cells, indicating that bilobalide protects the heart muscles.

[ConservativeMind]

For those with heart conditions, it appears ginkgo biloba extract is a legitimate and useful adjunct to other supplements.

[ConservativeMind]

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[tired&retired]

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[Deaf Smith]

Is this a FYI or PSA for those that take the Experimenatal Gene Therapy shots for China Virus 19?

[tired&retired]

TCA Cycle = Citric Acid Cycle = Krebs Cycle

[tired&retired]

Bilobalide is important for producing several of the effects of Gingko biloba extracts, and it has neuroprotective effects, as well as inducing the liver enzymes CYP3A1 and 1A2, which may be partially responsible for interactions between gingko and other herbal medicines or pharmaceutical drugs.

Bilobalide has recently been found to be a negative allosteric modulator at the GABAA and GABAA-rho receptors. Of GABAA, it may possibly be selective for the subunits predominantly implicated in cognitive and memory functioning such as α1.

[Bob434]

Be very careful of Ginko if you have any kind of bleeding condition- it can and does cause spontaneous bleeding=- Speaking from experience-

[tired&retired]

Excellent article on Gino’s and Immune function

Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats

https://www.tandfonline.com/doi/full/10.1080/00498250701883233?scroll=top&needAccess=true

[Arcadian Empire]

Ginkgo Biloba is great.

[Secret Agent Man]

Gingko Biloba also is a natural blood thinner

So just know that if you already take aspirin or other blood thinners

I take it every day

[thinden]

Ginko bump

[Steve Van Doorn]

THE most important ATP-producing processes in the mitochondria is melatonin.

mitochondria health Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders (very detailed report)
https://www.mdpi.com/2076-3921/10/9/1483/htm

Melatonin - sleep cycles Russel J. Reiter Doris Loh
https://www.youtube.com/watch?v=I7YIRqTNmuY&t=1s

[ckilmer]

I don’t have any heart issues.

Is your point, however that even if you don’t have heart issues—ginko is a good supplement to take to maintain your overall health.

[tired&retired]

Yes... but watch interactions with other drugs

[ckilmer]

I don’t take any blood thinners. But I do take 4 grams of omega 3. My understanding is that omega 3 has some blood thinning properties. What have you heard?

[tired&retired]

Per Drugs.com

“No interactions were found between Ginkgo Biloba and Omega-3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.”

[ckilmer]

what dose of ginko biloba do you take?

[tired&retired]

I take 500 MG. 2 per day.

One morning, one at 5 pm.