Posted on 02/23/2022 6:28:10 PM PST by ConservativeMind
Annual MRI screenings starting at ages 30 to 35 may reduce breast-cancer mortality by more than 50% among women who carry certain genetic changes in three genes, according to a comparative modeling analysis.
The predictions involve pathogenic variants in ATM, CHEK2 and PALB2 genes—which collectively are as prevalent as the much-reported BRCA1/2 gene mutations. Authors of the study contend that their findings support MRI screening in some of these women earlier than existing preventive-care guidelines propose.
"For women with pathogenic variants in these genes, our modeling analysis predicted a lifetime risk of developing breast cancer at 21% to 40%, depending on the variant," Lowry said. "We project that starting annual MRI screening at age 30 to 35, with annual mammography starting at age 40, will reduce cancer mortality for these populations of women by more than 50%."
"We also found that starting mammograms earlier than age 40 did not have a meaningful benefit but increased false-positive screens," Lowry added.
To realize a benefit of cancer screening guidelines based on genetic susceptibility, a woman would need to know she carries an implicated gene variant before receiving a disease diagnosis.
"People understand very well the value of testing for variants in BRCA1 and BRCA2, the most common breast cancer predisposition genes. These results show that testing other genes, like ATM, CHEK2, and PALB2, can also lead to improved outcomes," said Dr. Mark Robson.
"Overall what we're proposing is slightly earlier screening than what the current guidelines suggest for some women with these variants," said Dr. Allison Kurian. "For example, current NCCN guidelines recommend starting at age 30 for women with PALB2, and at 40 for ATM and CHEK2. Our results suggest that starting MRI at age 30 to 35 appears beneficial for women with any of the three variants."
(Excerpt) Read more at medicalxpress.com ...
So ordains the MRI full employment union.
Sure they do.
That explains why after my mom died from breast cancer, not ONE doctor ever suggested getting checked for it myself.
This is pretty typical of the inaction and outright negligence of the medical community in addressing health issues.
About the only thing the medical community has proven useful for is getting prescriptions for medicines I had already figured out I needed, which they always confirm, not because I told them, but because I made an appointment with a health need and they came to the same conclusion I already had.
As shallow, non-proactive, unimaginative, and apathetic as most of them are, I don’t see the value of the medical degree except to be a prescription writing service.
Sometimes I think a well-programmed computer which was fed symptoms could diagnose diseases even better than many doctors.
The breast MRI is the only test that has ever given me a panic attack. It’s the way you have to lay on the table and the length of the test (30-45 min). They had to stop the first try until I could come back after getting a valium from my doc...after which I got through it. I am considered very high risk because both my older sisters have had breast cancer as well as some aunts and great aunts. Each year I get a regular mammogram and then six months later the breast MRI. So far no cancer, thankfully!
What is the test for these genes.
This is one place to get this test:
https://www.genedx.com/tests/detail/breast-cancer-management-panel-833
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