Posted on 02/22/2022 3:23:50 PM PST by ConservativeMind
A study describes a new and effective therapy to treat glioblastoma: the concomitant use of ADI-PEG20 together with focal brain radiotherapy. This double treatment completely eliminated the tumor in the animal models used in the study.
Currently, glioblastoma is a terminal disease whose average life expectancy is less than two years. The treatments used at present are based on therapies that are more than 30 years old.
The results of this study offer a new therapeutic option against glioblastoma: the use of the drug ADI-PEG20, which eliminates systemic arginine, in combination with the application of focal brain radiotherapy. With this, it was possible to observe how a brain tumor, incurable to date, was completely eliminated in in vivo models that died of natural causes without showing any manifestation of the disease.
"With this new treatment, we were able to cure animals of an aggressive and terminal disease," says Dr. Sarmiento, "the post-mortem analyses detected how the cerebral immune response, and fundamentally the microglia cells, were activated during the treatment, directing their attack against the tumor cells and thus facilitating the tumor's complete elimination."
The data obtained are a ray of hope for the treatment of patients with this type of tumor, since, regardless of the success of the new anticancer drugs, their efficacy in the central nervous system is currently very limited, largely due to their difficulty in reaching the cancer cells located inside the brain.
Worth noting is another clinical trial (NCT04587830) also focused on another specific type of glioblastoma patient, studying the use of the same drug and whose results are proving to be very promising. Importantly, the drug did not manifest side effects in the patients involved in said trial.
The research team hopes to start of the Phase I clinical trial in the coming months.
(Excerpt) Read more at medicalxpress.com ...
exactly. Every disease known to mouse
You’d think by now mice would be able to live forever.
Except Covid. We skipped that testing. No need it always works. Right.
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