(forgive me -- it was the first thing that popped in my head!)
Posted on 02/19/2022 8:24:08 AM PST by ConservativeMind
An over-the-counter cough suppressant can knock some heart cells back into rhythm, a finding that may lead to a new way to treat a rare heart condition called long QT syndrome.
In people with long QT syndrome, heart cells are not always ready to produce the next beat, a situation that can knock the heart out of its normal rhythm, which may be life-threatening. For many people with long QT, no treatment can correct the heart cells or prevent arrythmia.
Heart cells in a dish
The cough suppressant discovery began several years ago when Yazawa found that heart cells in the lab would resume a normal rhythm when a certain enzyme was inhibited. But the drugs used to inhibit the enzyme also had other unintended effects, such as liver toxicity.
"We had to find alternatives," says Yazawa, assistant professor.
Yazawa's team reviewed published studies for ideas and learned that the enzyme could be inhibited through an intermediary molecule inside heart cells called SIGMAR1. Further reading suggested that SIGMAR1 could be targeted by a cough suppressant, dextromethorphan.
Heart cells on cough medicine
In the new study, Yazawa's team found that the cough suppressant, when added to heart cells, successfully prepared the heart cells for the next beat and soothed the cells' irregular rhythm.
The cough suppressant reset heart cells from people with Timothy syndrome, a genetic disorder that also causes other heart abnormalities, and from people with more common forms of long QT syndrome.
Yazawa cautions that it's premature to use dextromethorphan to treat long QT patients; the drug has a short half-life and would have to be used long term, which might still have unknown adverse side effects.
"Our study shows that drugs targeting SIGMAR1 have potential to treat a wide array of patients with long QT syndrome," says Yazawa.
(Excerpt) Read more at medicalxpress.com ...
Interesting thank you!
Surplengood for you for shizzle.
Interesting. I have afib which is a more common dysrhythmia. It won’t kill you (although stroke risk increases) but it sure feels like it will when you’re in it
And for me, the drugs are as bad as the condition
(forgive me -- it was the first thing that popped in my head!)
So if you have myocarditis from the vax, you should “Robotrip” on ‘Tussin”?...
I have learned something new today.
I have a heart condition including irregular heart beat several years, symptoms include dry night cough and higher than normal BP. Bought some DM cough syrup about 2 months ago…knocked out the cough immediately and BP has become stable at 120/70. Cardiologist said heart sounds more stable and regular. Instances of dry cough down to once a week from 3 times a week. Thanks for the info.
A medically beneficial use of “purple drank?”
It was patented in 1949 and approved for medical use in 1953.[8]
Since then, quad zillions of doses have been taken safely!
I read about Leary, was surprised at how immoral he was.
What name brands here in the U.S. contain the magic ingredient? Anyone know?
Common brands: Delsym 12 hour, Robafen Cough, Tussin Cough (DM only)
https://en.wikipedia.org/wiki/Dextromethorphan
bbb
I found out most DM liquid cough medicines contain this ingredient, including Amazon’s own, Rite-Aid, Robitussin (actually most Tussin DM’s. Lot of them have this ingredient. I went on Amazon to check this out.
bookmark
I have afib (diagnosed 10 years ago), and I was prescribed atenolol. I took the med at bedtime at first.
For years I had no problem. Then, 3 years ago, I probably had Covid a few months before we knew what Covid was.
A few months after whatever, I started having chills or hot flashes when I went to bed. Sometimes both symptoms in a night.
The page and a half of drug warnings about from my PPO pharmacy didn’t list chills and sweats as a side effect of atenolol.
A friend sent me a computer link to atenolol side effects, and chills and hot flashes were at the top of that list for atenolol.
So, I started taking atenolol with my morning meds. 2 days later, I was not having chills or hot flashes at bedtime.
and they have not returned.
I had a cardiac stent installed about 2 months before my covid crud or whatever. I was put on Eliquis, baby aspirin and another blood thinner. That may have saved my “bacon” re preventing cardiac clotting side effects post Covid and post Covid vaccinations.
Yup,
Wuhan coop in November 2019
Who knows what evil lurks
in its aftermath.
for later
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