Widely-used hormone drug associated with increased risk of benign brain tumor at high doses (cyproterone acetate (CPA))

Medical Xpress / Scientific Reports / University of Bristol ^ | Feb. 4, 2022 | Keng Siang Lee et al

[ConservativeMind]

High doses of a widely-used drug used in the hormonal treatment of conditions such as excessive hair growth, early puberty, prostate cancer, are linked to an increased risk of meningioma—the most common type of benign brain tumor.

Typically slow-growing, meningiomas are benign tumors, which are often revealed incidentally by imaging but can cause significant disability due to compressing or squeezing the adjacent brain, nerves and vessels and pressure effects within a fixed cranial vault.

High doses of cyproterone acetate (> 50 mg/day) is usually prescribed to male patients with inoperable prostate cancer, a condition which leads to excessive hair growth known as hirsutism, or male-to-female transsexual hormonal therapy. Lower doses (2-10 mg/day) of the drug are typically used with oestradiol to treat androgen-associated alopecia or female seborrhoea.

The team analyzed the occurrence in patients using high versus low dose cyproterone acetate and found a significant association between high dose usage and increased risk of meningioma. However, this association was not found with low doses.

Keng Siang Lee, lead author, said that "the cause of meningiomas is controversial but there is strong evidence to suggest a plausible role for sex hormones in the onset of meningioma. We know it has a predilection for females especially after puberty. Furthermore, fluctuations in meningioma growth during the menstrual cycle, pregnancy, and breastfeeding have also been well-documented. We are also aware of the well-characterized distribution of progesterone, estrogen, and androgen receptors in certain meningiomas located at the base of the skull."

"In light of these results, prescription of high-dose cyproterone acetate, especially for off label indications, should be considered carefully. Additionally, we suggest that routine screening and meningioma surveillance by brain MRI offered to patients prescribed with cyproterone acetate is likely a reasonable clinical consideration if given at high doses for long periods of time."

[ConservativeMind]

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[KTM rider]

This reminds me of watching network TV , where the constant stream of Big Pharma commercials has about 5 minutes of disclaimers and warnings at the end about how it may cause strokes , heart disease, sudden death, mental illness, empty bank accounts, etc etc

maybe the lobbiests can get this one mandated along with the mRNA "vax"

Neil Young wants to go first

[nicollo]

High doses of cyproterone acetate (> 50 mg/day) is usually prescribed to male patients with inoperable prostate cancer, a condition which leads to excessive hair growth known as hirsutism, or male-to-female transsexual hormonal therapy.

A dude might win a few girls swim meets w/ this drug, but the physical risk, as bad as it is as shown here, is far less severe than the emotional damage to all involved. Parents don't know how to say no to the public school/ social media/ psychiatric world that pushes these kids from adolescent confusion into permanent self-harm, and they, too, become victimized by it.

[Brookhaven]

“early puberty”

AKA puberty blocking drugs.