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Increasing incidence of early-onset colorectal precancerous lesions in patients under age 50
Medical Xpress / The Mount Sinai Hospital / Gastroenterology ^ | Jan. 11, 2022 | Steven H. Itzkowitz, MD, FACP

Posted on 01/11/2022 12:02:15 PM PST by ConservativeMind

Researchers describe a troubling increase in early-onset colorectal cancer and precancerous polyps, based on a large, nationally representative study of patients under age 50 who underwent colonoscopy. It was the first large-scale study to look at precancerous polyps in this age group.

"We have known for many years that rates of colorectal cancer are rising in individuals younger than 50, prompting several medical organizations to recommend lowering the screening age from 50 to 45. What has been missing until now is confirmatory data of the prevalence of precancerous polyps in younger individuals. Because precancerous lesions are not reportable to regional or national health agencies, we have not had this degree of information to guide our recommendations. Our study provides an important piece of the puzzle and supports the recommendation changing the screening age to 45," says lead author Steven H. Itzkowitz, MD. "Our findings also suggest that messaging aimed at young individuals should begin in the years leading up to this new screening age. We know that most patients do not call their doctors on their 50th birthday to schedule a colonoscopy, so we will need to be diligent to reach this much younger cohort before they turn 45," says Dr. Itzkowitz.

Increasing age, being male and white, having a family history of colorectal cancer, and having had colonoscopies for reasons of bleeding or screening, were all associated with higher odds of advanced premalignant lesions (APLs) and colorectal cancer. Among patients aged 45-49, 32 percent had neoplasia (precancerous or cancerous lesions considered forerunners to colorectal cancer). Nearly 8 percent had APLs, and 0.58 percent had colorectal cancer.

Early-onset colorectal cancer accounts for approximately 12 percent of all colorectal cancer cases, with incidence increasing by 2.2 percent annually from 2012-2016, and mortality increasing by 1.3 percent per year from 2008-2017.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: colonoscopy; colorectalcancer; polyps
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To: ConservativeMind

I won’t do this. Wouldn’t drink the laxative solution to begin with.


21 posted on 01/11/2022 12:38:19 PM PST by steve86 (Prophecies of Maelmhaedhoc O'Morgair (Latin form: Malachy))
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To: Yo-Yo
"Call me crazy, but if this is the first study of this age group, then how can they claim a "troubling increase" in the polyps? "

See my comment at #20.

22 posted on 01/11/2022 12:39:17 PM PST by mass55th ("Courage is being scared to death, but saddling up anyway." ~~ John Wayne )
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To: Yo-Yo

Lots of scientists are liberal. Lots of liberals are sloppy.


23 posted on 01/11/2022 12:40:20 PM PST by Rennes Templar (Come back, President Trump.)
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To: ConservativeMind

were these patients given vaccines? of any kind?


24 posted on 01/11/2022 12:41:02 PM PST by Diogenesis (Si vis pacem, para bellum)
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To: jagusafr
"I don’t know why a proctologist wouldn’t do a scope with light sedation."

My doctor uses Propofol for anesthesia, which doesn't leave you groggy. Periodically, I have a colonoscopy and gastroscopy done at the same time. I have woken up at least three times while they are doing the colonoscopy. When I had these last two procedures in June, I mentioned to the anesthesiologist that I have woken up in the past. When I woke up in the recovery room this time, he was there and said to me: "Guess what??" You didn't wake up this time."

25 posted on 01/11/2022 12:44:22 PM PST by mass55th ("Courage is being scared to death, but saddling up anyway." ~~ John Wayne )
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To: ConservativeMind

My mom gets her endoscopy and colonoscopy done here in LA without sedation..she refuses it, never has had it done never will. With me Ive always done it with profofol I wont do it any other way, I say the magic words “Knock me out” and its done..best sleep Ive ever had. Some doctors only do it with sedation so keep looking around, if you make the request to do it without sedation or very little sedation they will do it if that is what you want


26 posted on 01/11/2022 12:49:41 PM PST by Sarah Barracuda
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To: ConservativeMind

People under 50 have grown up with fast food, high pop intake, and nearly all processed foods.

No wonder.


27 posted on 01/11/2022 12:49:53 PM PST by setter
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To: mass55th
The worst part of a colonoscopy is the fasting and prep the night before

Yes! I agree. Hardest part for me is the FASTING. The wife decided to pan fry a steak and risotto the day before likely just to taunt me. I do not like going an entire day without eating.

I didn't think the prep was near as bad as others prepared me for. Started with 4 Ducalax tablets and then had two 32-Oz sugar-free Gatorade bottles spiked with Miralax. One at 6pm, one at 6am the following morning. I drink like a fish, so I rather enjoyed the drinks.

Then, spent quite a bit of time in what I consider my "natural habitat", but that can be a plus depending on how you choose to look at it. My advice would be to make sure your phone has a decent charge.
28 posted on 01/11/2022 12:50:02 PM PST by mmichaels1970
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To: ConservativeMind

Could it be caused by vaccinations impacting immunity?


29 posted on 01/11/2022 12:52:54 PM PST by alternatives? (The only reason to have an army is to defend your borders.)
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To: ConservativeMind

I woke up during my first one. Doctor did not like that.

A sigmoid scope can be done under light sedation if I remember correctly.


30 posted on 01/11/2022 12:56:14 PM PST by Karoo
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To: ConservativeMind

Title: Increasing incidence of early-onset colorectal precancerous lesions in patients under age 50

Body: ... based on a large, nationally representative study of patients under age 50 who underwent colonoscopy...
~~~~

In order to conclude what the article concludes the study would have to screen random cross sections of the 45-49 year old population in different years. This study did not do that. It merely gathered statistical data on the screening results of people who were screened for cancer in different years. One possible conclusion would be that fewer people were screened in later studies, people with more pronounced symptoms. And that would fit with the reluctance of candidates to get screened in a medical facility during COVID. Another possible conclusion would be that pre-selection of screening candidates improved over time.

This study was not capable of saying whether or not the incidence of colorectal cancer is increasing among 45-49 year olds. I remember back in the 1980s when oncologists were drumming up screening business based on new tests for the presence of blood in the stool. It turned out that virtually everyone has blood in the stool at some point.

Not everyone has cancer.


31 posted on 01/11/2022 12:59:12 PM PST by nagant
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To: ConservativeMind

See if your doctor will let you use the Cologuard test instead. If you get a negative on that they probably will deem that sufficient.

https://www.exactsciences.com/Our-Tests/Cologuard


32 posted on 01/11/2022 12:59:24 PM PST by Pelham (Q is short for quack )
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To: CatHerd

ping


33 posted on 01/11/2022 1:02:15 PM PST by Pelham (Q is short for quack )
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To: ConservativeMind

People stopped eating home cooked meals. They eat garbage now. Is there any wonder why this happens?


34 posted on 01/11/2022 1:02:45 PM PST by Vermont Lt
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To: Pelham
See if your doctor will let you use the Cologuard test instead. If you get a negative on that they probably will deem that sufficient.

I did that one. My doc told me that I could do the Cologuard every three years or get the full colonoscopy once every 10 years. I ended up doing both, but that's neither here nor there.
35 posted on 01/11/2022 1:03:55 PM PST by mmichaels1970
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To: mmichaels1970
"Hardest part for me is the FASTING."

I take oral medication for my Type II diabetes, so although they tell me to not take it the morning of the procedure, I don't take it the evening or at bedtime either, because I don't want to take the chance of being hypoglycemic during that fasting period.

My prep had to be started at 6 p.m., and then 8 ozs. every half-hour until it was finished. For diabetics, they recommend Crystal Light to mix with the prep. The only flavor you can use is their lemonade mixture, because they tell you, no red liquid. I hate Lemonade. I've had many colonoscopies. This one was the worst. I think I had one or two cups of the stuff left, but felt so bloated that when I tried to drink anymore, I gagged, so stopped. I didn't start crapping until three hours later, and was still hitting the toilet at 2 a.m. I'd never had a problem with "accidents" before, but something told me to buy myself a package of Depends this time around. I'm glad I did, because as soon as I'd get back on the sofa, I'd have to get right back up, and I was glad I had those throwaways on, as I was hurrying to the bathroom down the hall. Went through quite a few of them that night. Hopefully that was my last colonoscopy and prep. I'm 74, and asked my doctor how many more times I have to do the prep, and he said we could probably do the screening tests from now on. I'll still have to get gastroscopies, but at least I won't have to do the prep.

36 posted on 01/11/2022 1:04:08 PM PST by mass55th ("Courage is being scared to death, but saddling up anyway." ~~ John Wayne )
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To: ConservativeMind

Why? The sedation is easy to deal with. Don’t put it off. My wife had to use a bag for six months. You don’t want to risk that.


37 posted on 01/11/2022 1:04:21 PM PST by Vermont Lt
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To: steve86

Trust me, you don’t want colon cancer. The process of eliminating waste after they’ve removed a foot of your colon is not fun.


38 posted on 01/11/2022 1:07:38 PM PST by Vermont Lt
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To: ConservativeMind
EVERY histology report from a colonoscopy procedure will include the words "pre-cancerous" or "atipia". Just like when dermatologists send a sample to the histo lab.

Every cell in your body is "pre-cancerous" but having that word on the report is all about 1) defensive medicine and 2) scare tactics to help convince patients to sign up for more scheduled diagnostic procedures.

Just in case.

39 posted on 01/11/2022 1:10:15 PM PST by corkoman
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To: mmichaels1970

I’ve used the Cologuard a couple of times. It’s convenient and easy. The test detects DNA markers. I think it’s accuracy is considered to be around 98%.

If you have a history of polyps or cancer in your family your doc would likely insist on a colonoscopy to get that remaining 2% covered but otherwise this test is the way to go.


40 posted on 01/11/2022 1:12:21 PM PST by Pelham (Q is short for quack )
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