I've got a couple of cowboy guns with swappable .22 LR / .22 WMR barrels. Switching over to the .22 WMR is definitely a lot louder.
I have an EAA Single Six with swap out cylinders 22/22mrf...Got rid of that plastic Keltec. Only problem now is that I have a thousand rounds of MRF that I’ll probably never shoot through it.