Posted on 12/13/2021 8:22:37 AM PST by ConservativeMind
In cold conditions, brown adipose tissue (BAT) or brown fat generates heat to keep the body warm. Compared with white adipose tissue, BAT has more mitochondria—subcellular organelles associated with energy production—which allows it to burn calories and produce heat by activating the mitochondrial uncoupling protein 1 (Ucp-1). The stimulation of the sympathetic nervous system (SNS) after cold exposure, exercise, and calorie restriction is well known to induce fat browning. Dietary polyphenols may also activate BAT, causing heat to be dissipated from our bodies. BAT activation and white fat browning are thus both therapeutically significant in the fight against cardiovascular diseases and their comorbidities.
A group of scientists examined the browning of fat induced by dietary administration of flavan 3-ols (FLs), a family of "catechin" containing polyphenols abundant in cocoa, apple, grapeseed, and red wine. A new study proved that FLs enhance browning of adipose tissue by activating the SNS. The findings revealed a direct correlation between fat browning and FLs consumption.
The team then used the obtained adipose tissue to investigate the effects of long-term FL treatment. They were thrilled to discover that the white fat of mice who were fed FLs for 14 days eventually turned brown. Some of these cells also had notable structural changes, such as "multilocular phenotype," and appeared to be smaller than normal cells. Scientists showed that Ucp-1 levels, as well as other high temperature-linked proteins, increased in mice fed repeated doses of FLs. Browning markers, referred to as "beige markers" in this study, were also abundant in these mice. "All of these proteins work together to induce the development of the BAT phenotype," exclaims Prof. Osakabe.
Interestingly, this is not the first time FLs have worked wonders. Improvements in glucose and insulin tolerance have been seen after just one dose of FL-rich food administration.
(Excerpt) Read more at medicalxpress.com ...
“a family of “catechin” containing polyphenols abundant in cocoa, apple...”
Wow, great news. Can I lose weight on a diet of chocolate ice cream and apple pie?
Hot flavonoids, followed by a long cold shower and an ice bath dip...the new diet craze!
Bookmark
“(White fat becomes brown fat, which is easier to burn off)”
Did someone add this to the title?
White fat does not become brown fat.
Brown fat does not burn off.
Brown fat did evolved from muscle tissue.
Brown fat does burn fat to produce heat.
think flavanols are the same as flavanoids or bioflavanoids?
Flavonoids And Bioflavonoids: A Review
Danielle Smith Anderson, ND, M.A., L.ac
PRINT
SHARE
Although flavonoids and bioflavonoids have long been incorporated into the care plans of many, individuals may be unaware of the role they play. The following are a few clarifications for what these plant powerhouses are, where they came from and how to investigate them, and suggestions during recommendations.
Flavonoids and Bioflavonoids: Plant Powerhouses
Flavonoids are characterized as a plant pigment that is found in many fruits and flowers. The name ‘flavonoid’; which has the Latin stem, ‘flavus’ means yellow. The common colors for these particular pigments are red, yellow, blue, and purple. The pigments are found in the cytoplasm and plastids of flowering plants. As opposed to other pigments such as chlorophylls, carotenoids, or betalains, certain flavonoids play a distinct role in fruit ripening and capturing certain variants of light within the UV spectrum. They seem to be highly prevalent in plants from the citrus family, as well as pigments common in tea, red wine, dark chocolate, and richly-colored berries.1Bioflavonoids are polyphenolic compounds found in plants. There are over 5,000 bioflavonoids identified throughout the plant kingdom, many of which have been the subject of preclinical and human research.2 Bioflavonoids have been widely recognized to affect a wide range of systems in the body.
A History and How to Investigate
Individuals are encouraged to understand the plant sources of these compounds for dietary management, as well as the use of dietary supplements containing these ingredients. In order to fully utilize these compounds, it is important to note and differentiate the various terms used throughout the supplement industry, within peer-to-peer conversation, and searchable terminology utilized during research studies.The use of the terms flavonoid and bioflavonoid are essentially interchangeable. Historically, bioflavonoids or flavonoids were called vitamin P. You will often see the term vitamin P in early studies before the 1980’s. There are numerous classes of flavonoids including isoflavones, anthocyanins, flavanones, flavonols, to name a few.3While investigating applicability of flavonoids within a care plan, bear in mind these classes and utilize their name variants when attempting to compile a comprehensive list of available literature. Four types of flavonoids have been researched for clinical use. These include: polyphenols derived from tea, quercetin and its diverse molecular cousins, citrus bioflavonoids, and proanthocyanidins found in grapes and certain pine species.4 These four types are often broadly categorized in abstracts of research articles.From a biochemical prospective, flavonoids are characterized by a hetercyclic oxygen ring. This unique aspect of their make-up can help to identify and differentiate a flavonoid from other pigments in the animal kingdom. Depending on the group of flavonoid, there may be various constituents attached to this hetercyclic oxygen ring.5 For example, flavonoids in the subclass quercetin have a similar structure and certain conventional therapeutics. Its mechanisms can be investigated with this in mind.5 Identifying the various constituents attached to a heterocyclic oxygen ring can aid in identification of which class of flavonoid the food, herb, or active ingredient belongs to as well.
Recommending Bioflavonoids
When recommending a bioflavonoid or complex of bioflavonoids as part of a comprehensive plan, practitioners should attend to the concerns of bioavailability. Many bioflavonoids are less bioavailable as the dose increases. Therapeutic dosing of bioflavonoids is often paired with technology that enhances bioavailability. For example, quercetin has a low bioavailability. Research shows oral administration of quercetin results in a low absorption and utilization, and when given via IV administration, it metabolizes within a few hours.5Two ways supplement manufactures are addressing the issues of bioavailability and absorption are by creating delivery of bioflavonoids in a water-soluble form, which can reach the blood stream more effectively, or in a lipid soluble form for a slower, but effective rate of absorption. Without a proper delivery method, absorption has been shown to be very low. Many common bioflavonoids (such as those containing vitamin C) are water-soluble and perform best in formulas that allow for proper delivery.It should be noted that microorganisms in the gut degrade flavonoids. Balancing gut flora is recommended to optimize utilization of bioflavonoid compounds. Healthy digestion plays a key role in the ability of the body to absorb flavonoids effectively. Bioflavonoids are best taken on a full-stomach, and when done so will aid in obtaining an increased amount of absorption.6 When determining clinical applicability in research, take note of the form used within the research studies to evaluate the effective form needed to deliver the appropriate type of bioflavonoid.While the surface of the topic of flavonoids and bioflavonoids has barely been scratched, it has also been said that brevity is the soul of wit. With the above in mind, there is certainly a place for a deeper understanding of what flavonoids are, how they function within the body and how to properly identify, investigate, and integrate them within clinical practice.
This is good!
Between the cocoa in my coffee each morning and the glass of wine reward for cleaning the kitchen after supper each night, I’m at 2 out of 4 just being me … and hopefully a warmer, little less of me, too, all winter.
Wow, great news. Can I lose weight on a diet of chocolate ice cream and apple pie?
—
Yes but the pie must be homemade and the chocolate, dark. Ordering AAPL pie as we speak.
I added it, and it comes directly from the article you didn’t read.
oh fantastic! Drink those teas and don’t drink wine. but do eat apples! Appreciate your post!
“I added it, and it comes directly from the article you didn’t read.”
Perhaps your level of English comprehension is not what you think it is.
And once again, being White is bad.
-PJ
“…white fat of mice who were fed FLs for 14 days eventually turned brown…”
“Compared with white adipose tissue, BAT (brown adipose tissue) has more mitochondria—subcellular organelles associated with energy production—which allows it to burn calories and produce heat by activating the mitochondrial uncoupling protein 1 (Ucp-1).”
“Hot flavonoids, followed by a long cold shower and an ice bath dip”
Hot flavonoids (but otherwise fasting), grueling high intensity interval training, and ice cold showers.
Even if you don’t actually live longer, it will seem like a lot longer.
And where does it say “... brown fat, which is easier to burn off”?
Is English your native language?
We need a meme, with that guy saying “Got any more of those....hot flavonoids?”
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.