Melatonin exacerbates asthma (Bloodstream amounts for asthmatics is okay)

Medical Xpress / ResearchSEA / American Journal of Physiology-Lung Cellular and Molecular Physiology ^ | Dec. 10, 2021 | Haruka Sasaki et al

[ConservativeMind]

Asthma sufferers generally find their condition gets worse at night. Now, a research group may understand why. Melatonin, a sleep hormone that is sometimes prescribed to treat insomnia, exasperates the constriction of the bronchus—the pathway that moves air to and from the lungs.

Patients with asthma often experience a worsening of asthmatic symptoms at night in so-called "nocturnal asthma." According to reports, more than 50 percent of asthma deaths occur at night, exposing a link between nocturnal asthma symptoms and asthma deaths. Although some have proposed several triggers that explain the pathogenesis of nocturnal asthma, the precise mechanisms regulating this asthma phenotype remain obscure.

Now, a research group has discovered that melatonin, a sleep hormone, worsens asthma.

Asthma patients suffer from bronchoconstriction, where the smooth muscles of the bronchus—the pathway that moves air to and from your lungs—contract. To ease this, many take a bronchodilator, a medicine which widens the bronchus.

However, melatonin, which is often prescribed for insomnia, favors a state of bronchoconstriction and weakens the relaxing effect of a bronchodilator through the activation of the melatonin MT2 receptor.

To elucidate this, the research group identified the expression of the melatonin MT2 receptor in human airway smooth muscle. They observed that the activation of the melatonin MT2 receptor with higher doses of melatonin or melatonin receptor agonist ramelteon greatly potentiated the bronchoconstriction. Furthermore, melatonin attenuated the relaxing effects of the widely used bronchodilator β-adrenoceptor agonist.

"Although serum concentration of melatonin did not significantly induce the airway constriction, greater doses of melatonin, which is clinically used to treat insomnia, jet lag, or cancer, worsened asthma symptoms and impaired the therapeutic effect of bronchodilators," said Mizuta.

First author of the paper Haruka Sasaki adds, "The pharmacological therapy that blocks the melatonin MT2 receptor could inhibit detrimental effects of melatonin on airways."

[ConservativeMind]

It’s fine for everyone else.

[ConservativeMind]

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[Faith65]

bkmk

[HartleyMBaldwin]

“Melatonin...exasperates the constriction of the bronchus...”

Exasperates? I guess if two words sound about the same, it makes no difference which one you use.

[BusterDog]

I’m on the Mel. 12mg each night.

[Mr. K]

Take Niacin with it
It does not help sleep though-the right mix of niacin/melatonin actually gives you energy - without that Niacin ‘flush’

[Qiviut]

For those without asthma ....

Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395320/

[throwthebumsout]

“Melatonin as a Potential Adjuvant Treatment for COVID-19”

It is a treatment for the Coof. Therefore, it must be villainized.

[DannyTN]

1mg works for me. More than that, and it has a reverse effect. I use it when my sleep cycle gets off. Which happens often as I’m from a planet with a 32 hour circadian rhythm.

[Delta 21]

Great. Sleep apnea for 20 years and melatonin suggested for help with sleep the entire time as well as in the “covid-kit” to help you rest when you get sick.

I have been looking for why they recommend it in the covid kit and alls I can find is to help you get to sleep. No indication that it helps any other way to fight the bug other than helping you sleep.

This coinciding with a major recall by the makers of CPAP machines. The new ozone generating “;azy folks mask cleaners” use OZONE, a radical oxidizer, to clean your mask when your not wearing it. The ozone is breaking down the internals of the machine into microscopic particles that are in the breathing pathway so millions of users have been breathing in microscopic chunks of foam rubber for who knows how long!

Does anyone know any specifics, other than helping you rest, on why its included in the covid kit recommendations.

Its getting pretty FUBAR out there folks.

Thanks.

[Qiviut]

Exactly.

[steve86]

Looks like a spelling autocorrect that should have been caught in editing.

[Delta 21]

Thanks for answering some of my questions before I asked.

[HartleyMBaldwin]

Maybe. I’ve heard that misuse in conversation, too.

[steve86]

“No indication that it helps any other way to fight the bug other than helping you sleep.”

Actually melatonin is very high in antioxidants and might benefit through other mechanisms as well.

“The results showed that melatonin acts to reduce reactive oxygen species–mediated damage, cytokine-induced inflammation, and lymphopenia in viral diseases similar to COVID-19.”

[Qiviut]

Interesting ‘factoid’:

Melatonin is on the FLCCC’s protocols for prevention, early outpatient treatment AND treatment for hospitalized patients

https://covid19criticalcare.com/covid-19-protocols/math-plus-protocol/

[Reeses]

Justin Trudeau said he tried for years, but Melanin 20 mg has absolutely no effect on sleep.