I don’t know much about Jamestown or have forgotten. Except there was a word carved somewhere or something.
I think you are probably thinking of Sir Walter Raleigh's colony at Roanoke. The ship returned to England after delivering the colonists. After delays, they returned to find the settlement deserted and this carved into a tree: "CROATOAN"
No one is sure what that is supposed to mean and subsequent searches never turned up another colony. Archeologists to this day haven't solved the mystery.