They have big genetic issues with cancer and other diseases. If you think you are in that bloodline you need to watch for cancer and take advantage of free cancer genetic tests when available...like BRCA. I cant remember the hoops you have to jump through but they go to the head of the line.
Also pancreatic cancer.
There is even a gene panel for you of some known diseases
https://www.uofmhealth.org/health-library/tv7879
Folks with Ashkenazi blood are also prevailing carriers of NCCAH, an autosomal defect of the endocrine system.
I know this from personal experience.
You have to take the bitter with the sweet.