Virology 101 from Treepers. Do they have it right?
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regitiger
October 4, 2021 1:02 am
Reply to ncxplant
...as the c19 virus is pressured by the mRNA group, mutations will select a higher affinity for transmissibility. This is one known prediction. The other prediction is that there is a high potential the mRNA will pressure the c19 to select for new features also….Such as the potential to target other cells for replication beyond just the one, ace2 receptor. This latter prediction is very worrisome, and yet the chances cannot be measured. We do not know how the mRNA vacinne will operate at scale over dwell time. But we have some anecdotal evidence, simply by examining HOW GAIN OF FUNCTION PPP virus experiments operate. In the lab, the entire mission is to pressure a virus to select higher transmission and pathogenicity. There are dozens of successful experiments that concluded in producing auto-immune GOF chimeras from otherwise mundance and rather harmless virus. So there is the possibility.
what does this mean to the trajectory of c19? What does it mean for the unvaxxed?
first q: it means c19 is likely than not to continue mutating for higher and higher transmission capability. And this means there is a very good chance it will also take on new features to target multi cells for replication. This would then become a NEW AND NOVEL Virus all over again. Of which No One would have any prior immune memory. Not good. but worse than novel, a virus that alters DURING a pandemic, with billions of people already exposed and with less than optimal immune health due to the existing constant exposure and pressure of the virus to the human body at large. Being that mRNA trains the quota limit of the human immune response to c19 spike proteins that are no longer in circulation, this means the vaxxed group will be at highest risk of severity and death.
second q: while the unvaxed, presuming prior exposure and immune response has been furnished and remains durable, are less likely to be at risk versus the vaxxed, the reality is that this will be a temporary condition….If the virus acquires a significant transmissibility factor, this means the potential viral load factor goes up. What the body could defend against at smaller viral loads might break down under the assault of a large viral threat. Viral load and transmissibility are positively correlated with c19. (and almost all other viruses studied)…If the c19 gains new functions such a multi-cell targeting capability, unvaxxed will be faced with a novel virus.
my prediction is that the vaxxed group will experience the most risks due to the mRNA..and that is not counting the damage from the mRNA directly. It’s very likely the combination of illness and less than optimal effects the mRNA vax has PLUS the c19 variants it will pressure to achieve, will have an overwhelming deleterious health effect on the vaxxed. The unvaxxed will not have this additional delimit, and will probably have a much higher odds of beating back the newer mutations. But if the c19 does acquire new multi cell targeting…that really changes everything. Predictions are useless as we have no data to show what happens when a sars like pandemic goes auto-immune. But we have anecdotal evidence how that might shape out. Again, we need only to observe the details of the line passage GOF PPP experiments to get some ideas. HIV/AIDS is a real world lesson in auto-immune virus ….a virus that continues to kill millions and has never really stopped killing…a virus that achieved multi-cell capability.
More Virology 101:
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Black Irish Rose
October 4, 2021 12:15 pm
Reply to ModernThrowback
I don’t think natural immunity wanes, but what does wane are the number of antibodies actively circulating in our system for any given encountered and defeated disease. AND it is a good thing we do NOT carry around high numbers of antibodies from every virus we encountered and defeated because our lymph nodes (located all over the body) would each have to be the size softballs! We would look like walking tumors, globs protruding out of our necks, underarms, groin area, to name just a few places……
No, what happens is the antibodies hang around after initial infection and disease elimination. When the “all clear” is given, antibodies do decrease, but T cells and B cells take over. Both are memory cells but function differently. The T cells are very small in number, and they circulate, making the rounds at it were, with a covid19 blueprint at the ready (for ALL of the virus, not just for the spike protein). If encountered, the T-cells then multiply to attack. This is why you may feel ill for a day or two, as the T-cells are amassing to fight.
The B-cells also have the same blue print, but unlike T-cells, they reside in the bone and do NOT replicate when an attack is underway. The B-cells stay in the bone as memory cells for the immune system and every day, for the rest of your life, whatever virus you successfully fought, you have B-cells in your bones that send out a few signals to reconnoiter the joint (your body), looking for viruses past. Now, the strep throat you had a age 4 probably has no T cells circulating anymore, but the B-cells are still there and they remember. They probably aren’t doing much looking/sending anymore, as that strain has long since died away/mutated itself out of existence from the original. But the flu you had a couple years ago? Yes, those T cells and B cells with that virus blue print are still on the job, still on the look out.
So if you had covid19, the antibodies protecting you from another infection are going to hang around for awhile, but not in same numbers as if your body was under attack. For the unvaxxed: They haven’t injured, rewired or altered their bodies’ ability to form T and B cells, so they should be fine. It’s anybody’s guess how natural immunity will fare if the gain of function goes sideways in ways we don’t yet know about. My money is till on natural immunity, though 🙂 (PS-this is how a doctor explained it to me re: antibodies, T cells and B cells. I don’t have a science mind or background, so this helped me understand.)