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Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19
Science Direct ^ | 09/2021 | A.D.Santin, D.E.Scheim, P.A.McCullough, M.Yagisawa, T.J.Borody5

Posted on 09/28/2021 10:23:54 PM PDT by SeekAndFind

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1 posted on 09/28/2021 10:23:54 PM PDT by SeekAndFind
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To: SeekAndFind

Appendix A. Supplementary data: The following is/are the supplementary data to this article:

Download : Download Acrobat PDF file (326KB)
2 posted on 09/28/2021 10:25:32 PM PDT by SeekAndFind
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To: SeekAndFind

Thanks for this. Ivermectin is an FDA-approved drug for humans, so there’s no reason not to try it. As former President Trump said, albeit in a different context, “What have you got to lose?”. Ultimately I trust the guys and gals with medical degrees far more than I trust the politicians.


3 posted on 09/28/2021 10:27:23 PM PDT by FormerFRLurker
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To: SeekAndFind

About the Authors:

1) A.D.Santin

Department of Obstetrics & Gynecology, Yale University School of Medicine, New Haven, CT, USA

2) D.E. Scheim

US Public Health Service, Inactive Reserve, Blacksburg, VA, USA

3) P.A. McCulloagh

Texas A & M College of Medicine, Dallas, TX, USA

4) M. Yagisawa

Ōmura Satoshi Memorial Institute, Infection Control Research Center, Kitasato University, Tokyo, Japan

5) T.J. Borody

Centre for Digestive Diseases, New South Wales, Australia


4 posted on 09/28/2021 10:27:55 PM PDT by SeekAndFind
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To: FormerFRLurker

About the Authors:

1) A.D.Santin

Department of Obstetrics & Gynecology, Yale University School of Medicine, New Haven, CT, USA

2) D.E. Scheim

US Public Health Service, Inactive Reserve, Blacksburg, VA, USA

3) P.A. McCulloagh

Texas A & M College of Medicine, Dallas, TX, USA

4) M. Yagisawa

Ōmura Satoshi Memorial Institute, Infection Control Research Center, Kitasato University, Tokyo, Japan

5) T.J. Borody

Centre for Digestive Diseases, New South Wales, Australia


5 posted on 09/28/2021 10:28:50 PM PDT by SeekAndFind
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To: SeekAndFind

Thanks for posting.


6 posted on 09/28/2021 10:29:04 PM PDT by Jane Long (What we were told was a “conspiracy theory” in 2020 is now fact. 🙏🏻 Ps 33:12 )
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To: Mrs. Don-o; tellw; Huskrrrr; Jane Long; Freedom'sWorthIt; Freedom56v2; BDParrish; Phx_RC; cba123; ..

Ping for your interest


7 posted on 09/28/2021 10:29:26 PM PDT by SeekAndFind
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To: SeekAndFind

Bttt


8 posted on 09/28/2021 10:51:21 PM PDT by Eagles6 (Welcome to the Matrix . Orwell's "1984" was a warning, not an instruction manual.)
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To: SeekAndFind

Anyone fortunate enough to have their physician prescribe Ivermectin for them?


9 posted on 09/28/2021 10:58:31 PM PDT by TheDon (Resist the usurpers)
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To: SeekAndFind
Now here is something that God sent, Governor Hochul.

Ivermectin:
The avermectin family of compounds was discovered by Satoshi Ōmura of Kitasato University and William Campbell of Merck. In 1970, Ōmura isolated unusual Streptomyces bacteria from the soil near a golf course along the south east coast of Honshu, Japan.[7]

Ōmura sent the bacteria to William Campbell, who showed that the bacterial culture could cure mice infected with the roundworm Heligmosomoides polygyrus.

[7] Campbell isolated the active compounds from the bacterial culture, naming them "avermectins" and the bacterium Streptomyces avermitilis for the compounds' ability to clear mice of worms (in Latin: a 'without', vermis 'worms').[7]

Of the various avermectins, Campbell's group found the compound "avermectin B1" to be the most potent when taken orally.[7]

https://en.wikipedia.org/wiki/Ivermectin#Chemistry

10 posted on 09/28/2021 10:58:56 PM PDT by Karl Spooner
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To: TheDon

No.


11 posted on 09/28/2021 11:20:12 PM PDT by RushIsMyTeddyBear (RIP my "teddy bear". )
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To: Karl Spooner

Humble beginnings, from something found in dirt to a multi-use drug with many important applications..

Penicillin had a similar birth.. from mold growing on cantaloupe rinds in a laboratory sink to indispensable antibiotic miracle drug. Although it would be a sub-optimal choice for treating pneumonia today it was once basically the only treatment... the choice now would be something like Doxycycline.


12 posted on 09/28/2021 11:24:02 PM PDT by Bobalu (The plan must be to distract from Afghanistan by doing something even more stupid )
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To: SeekAndFind

It’s the cure for most people, for early covid. And it works prophylactically. I’m on it, the horse paste lol.


13 posted on 09/28/2021 11:44:32 PM PDT by Basket_of_Deplorables (Convention Of States is our only hope now! Desantis 2024!!!)
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To: TheDon

I found a doctor that was willing to prescribe Ivermectin, but so far I haven’t found a pharmacist that will fill it. Many pharmacists are willing and even sympathetic. However, they are being overridden or directed at a higher level to not prescribe. They cite safety, which can clearly be shown to be untrue. When pointed out that the drug has been around for 35 years with no safety issues, they then shift to claim there has been no trials showing Ivermectin to be effective for covid. That’s not true either. There are trails that show effectiveness. They just don’t want to look at them.

Welcome to the Brave New World where medical personnel surrender their professional integrity to become cringing cowards in the face of the political agenda of an insidiously corrupt, self-appointed elite. Utopia is surely just around the corner.


14 posted on 09/29/2021 12:02:56 AM PDT by Prince Caspian
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To: Basket_of_Deplorables

15 posted on 09/29/2021 12:08:03 AM PDT by Bobalu (The plan must be to distract from Afghanistan by doing something even more stupid )
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To: TheDon
Anyone fortunate enough to have their physician prescribe Ivermectin for them?

Yes, my older daughter's physician did. She's a PureBlood, like me. My own Primary Care Physician declined, but pointed me to a nearby hospital that is offering the monoclonal antibody treatment.

Neither of us have managed to catch the bloody virus, however

16 posted on 09/29/2021 12:43:27 AM PDT by Chad C. Mulligan
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To: Bobalu

Lmao. I went to tractor supply and they are plastering the shelves with warnings against human use and that it does not treat covid.


17 posted on 09/29/2021 12:57:40 AM PDT by JudgemAll (Democrats Fed. job-security in hates:hypocrites must be gay like us or be tested/crucified)
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To: TheDon

My niece in Georgia has doctors who have prescribed it. With the certain knowledge that our communist overlords in the medical industrial complex are lying to us at every turn, they use concierge providers.

I’m not sure, but I think that even with prescriptions, having pharmacists turn it over is becoming a problem.


18 posted on 09/29/2021 1:36:41 AM PDT by MayflowerMadam (“If TPTB can force you to take a shot, what CAN'T they force you to take?” - T. Carlson (paraphrased)
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To: SeekAndFind

The key to Ivermectin working is to have Ivermectin at a level of greater than 160 nanograms / liter in the blood. (One billionth (10−9) of a gram.)

Ivermectin taken with food,has been discovered to be very effective at killing the virus at this level of dosage , which in this study is 6 mg per kilo of body weight :

“High Dose Ivermectin And COVID-19: High Doses, Systemic Concentrations, And SARS-CoV-2 Viral Loads!”

https://www.youtube.com/watch?v=wsJPZPB93Qc

************************************

Be prepared:

The vaccine is a dead end path to coping with Covid.

Eventually it will not work at all.

Immunity is 27 times more effective than any Vax.

So how do we get immunity? We use drug therapy once infected, and we all sooner or later will be infected, its like the common cold, unavoidable.

The best so far is Ivermectin based drug therapy.

The proper approach to conquering the virus is one like we use for malaria.

Ivermectin therapy should be over the counter, non prescription, and used according to established protocols with which we can educate the public.

If you cannot get a physician’s prescription, you can order it here:( Use Pay Pal)

1) Zivirdo Kit:

https://dir.indiamart.com/search.mp?ss=Zivirdo&prdsrc=1&countryiso=USA ( get enough to make sure your dosage is right for your weight...carefully read the protocol linked below )

2) Ivermectin Tabs ( get 12 mg tabs)

https://dir.indiamart.com/search.mp?ss=ivermection+12+mg&prdsrc=1&src=as-popular%3Akwd%3Divermect12%3Apos%3D1%3Acat%3D-2%3Amcat%3D-2&qu-cx=1&countryiso=USA

***************************

Protocols to follow for both Prophylaxis and Therapy for Infection:( read it in detail before ordering)

https://covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-I-MASK-Protocol-v4-2020-11-22.pdf

Ivermectin is no longer a banned treatment by the CDC. They are just “not recommending” it.The reason that the government is so afraid of Ivermectin is that it likely clears the circulation system of ALL stick proteins whether generated by the VAX or by the Virus. So it will likely reverse the effect of the jab.

You will need over the counter Zinc, Vitamin D and Quercetin supplements.Available on line or at larger drug stores.

Hundreds of Feepers stocked up over the last 6 months.

********************************

https://www.researchgate.net/publication/343390023_Ivermectin_docks_to_the_SARS-CoV-2_spike_receptor-binding_domain_attached_to_A

There is reasonably solid evidence that ivermectin docks to the spike protein itself to prevent binding to the ACE2 receptor which is the primary pathology causing the tissue damage and clots related to SARS-CoV-2. Therefore, this is also an implication that this ability of ivermectin to disable the binding of the Spike protein including the vaccine-produced spike proteins. This binding of ivermectin to disable the spike protein is also preserved even with the newer spike protein mutations, but its activity against the original Wuhan spike protein,(the one vaccines were designed to produce) is fairly well studied at this point.

Abstract:

Background/Aim: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One drug that has attracted interest is the antiparasitic compound ivermectin, a macrocyclic lactone derived from the bacterium Streptomyces avermitilis. We carried out a docking study to determine if ivermectin might be able to attach to the SARS-CoV-2 spike receptor-binding domain bound with ACE2. Materials and Methods: We used the program AutoDock Vina Extended to perform the docking study. Results: Ivermectin docked in the region of leucine 91 of the spike and histidine 378 of the ACE2 receptor. The binding energy of ivermectin to the spike-ACE2 complex was -18 kcal/mol and binding constant was 5.8 e-08. Conclusion: The ivermectin docking we identified may interfere with the attachment of the spike to the human cell membrane. Clinical trials now underway should determine whether ivermectin is an effective treatment for SARS-Cov2 infection.

The following video [ https://www.youtube.com/watch?v=11Bl2v3BR2M ] explains the multiple mechanisms of the activity of Ivermectin including the ability of the body to maintain its basic defense of the cell nucleus in preserving the body’s ability to produce antiviral proteins, inhibition of RNA dependant RNA polymerase which inhibits the replication of viral RNA (possibly including that from the mRNA vaccine package), the stat 3 human signaling pathway which inhibits the production of blood clots also possibly mitigating some of the vaccines most dangerous side effects. Also discussed is the inhibition of the CD147 pathway by Ivermectin which again may block the clumping of platelets due to spike protein either from the virus or possibly the vaccines.

Note: Ivermectin therapy likely will gradually rid the body of spike proteins altogether, something to remember for those who might have residual side effects from mRNA vaccine.

******************************************************
Effective dosage of Ivermectin is 0.6 mg per kilo of body weight instead of the 0.2 recommended in the IMASK protocol.

Protocols to follow for both Prophylaxis and Therapy for Infection:( read it in detail )

https://covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-I-MASK-Protocol-v4-2020-11-22.pdf

The study is here:
“High Dose Ivermectin And COVID-19: High Doses, Systemic Concentrations, And SARS-CoV-2 Viral Loads!”

https://www.youtube.com/watch?v=wsJPZPB93Qc

*************************

( 0.6 mg per kilo of body weight yields greater than 160 nanograms of Ivermectin per liter of blood, at that level it eliminated the virus...side effects. rarely a rash, or rare salt deficiency ( NaCl).

**************************************************


19 posted on 09/29/2021 1:50:39 AM PDT by Candor7 ((Obama Fascism:http://www.americanthinker.com/2009/05/barack_obama_the_quintessentia_1.html) )
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To: Prince Caspian

See my post # 19 below, Sources of Ivermectin.Order takes about 30 days to arrive.


20 posted on 09/29/2021 1:53:52 AM PDT by Candor7 ((Obama Fascism:http://www.americanthinker.com/2009/05/barack_obama_the_quintessentia_1.html) )
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