Posted on 09/14/2021 10:20:20 AM PDT by rxsid
Do you keep a dedicated thread for this? I’d like to bookmark.
Right. That’s what they put on the paperwork, and maybe even what the FDA’s premise for the EUAs as well. But that is not how they spun it in the media - at least not for a while now and the experts I listened to didn’t push that it would prevent disease - just lower risk of serious infection or worse.
I have no idea what the FDA was thinking to allow this on the paperwork; then again, I wonder how great the data the FDA had to work with was. It’s been a while since I looked at the trial data (and even then only a little bit) but it seemed to me at the time my impression was that there was only very small distinction in raw numbers between the drug and placebo groups. Just large enough trial participants that it showed a “statistically significant” outcome. And that was before Delta variant it was all on the original first virus.
Each of the 3 vaccines under EUA were tested in different groups, at different times, with different external factors, different regions etc. All of those could have inserted bias into the results which is partly why you got them saying “this one is 90% effective” and “that one is 75% effective”. We now know those claims are 100% BS.
But then, they went and broke the blind (gave the drug to the placebo arm patients) within a few months so you can’t even go back and see how these people fared (better or worse or no change) after 3 or 6 months. In almost any other case that would have been a protocol violation and the drug would have had to go back and start phase 3 all over again. But the FDA went ahead and gave Pfizer a full authorization anyway - even knowing from other third pata data that its protection wanes quickly. Totally unorthodox.
Working on something, time permitting. Stay tuned....
If you’re starting a ping list, please add me!
Have you seen this thread? Accounts of those from FR, https://freerepublic.com/focus/chat/3988541/posts (updated in post#131)
Those who were exposed to SARS in 2003 have the antibodies to SARS COVID-19.
They’ve been trying to reduce the population for years. Abort the babies and kill off granny at 75.
Hundreds of millions dead, and generations of people made sympathetic to depraved and calloused infanticide, if not actually participant in it.
I guess there must at least be 10 genuinely righteous men in the country.
When I get the posts done on this issue though, covid vaccines/breakthrough cases/hospitalizations/deaths, I shall ping you to them.
yes, but if you read that study through, it’s not just vaccinated. The previously infected reacts the same way, by producing autoantibodies.
However, the authors find the solution to a hypothetical D4 in the last part of the paper :
” When we analyzed the Delta-4+ pseudovirus, some sera from wild-type spike immunized mice showed enhanced infectivity” (that would be ‘naturally acquired”) and “Sera from the Delta-spike immunized mice did not exhibit enhanced infectivity at any concentration of sera. These data suggest that vaccines containing the Delta, but not wild-type, spike might be required to control the Delta subvariant that may emerge in the future.”
Bottom line is, wipe out Delta and other variants before they mutate further:
“These data suggested that the Delta variant completely escaped from anti-NTD neutralizing antibodies while maintaining functional enhancing antibody epitopes. Because the enhancing antibodies decrease the effect of anti-RBD neutralizing antibodies (Li et al., 2021; Liu et al., 2021b), there is a possibility that the Delta variant maintains the infectivity in the presence of anti-RBD neutralizing antibodies as a result of enhancing antibodies.”
“We analyzed these 16 anti-NTD neutralizing antibodies, and found that none of the anti-NTD neutralizing antibodies could recognize Delta spike (Figure 1A). In contrast, when we analyzed the binding of the anti-NTD infectivity-enhancing antibodoies (Li et al., 2021; Liu et al., 2021b), eight out of ten anti-NTD enhancing antibodies bound to Delta spike at levels comparable with wild-type spike “
” Anti-RBD neutralizing antibodies that bound to the Delta spike completely neutralized the infection of either Delta or wild-type pseudovirus (Figure 1C). All anti-NTD neutralizing antibodies we tested failed to recognize the Delta “
“s. Because the enhancing antibodies decrease the effect of anti-RBD neutralizing antibodies (Li et al., 2021; Liu et al., 2021b), there is a possibility that the Delta variant maintains the infectivity in the presence of anti-RBD neutralizing antibodies as a result of enhancing antibodies.”
“All anti-NTD monoclonal neutralizing antibodies from COVID-19 patients failed to bind to Delta spike whereas most of the enhancing antibodies maintained reactivity to Delta spike “
ping natural immunity
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