You don’t shoot to kill,
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Depends on the circumstances. It’s always better to put a permanent end to thugs with guns. ALWAYS!
Practically though any shot can be fatal. That's why any use of a firearm is considered deadly force. We're trained to shoot center mass because that is typically the biggest target thus improving the chances of a hit. It is also the location of the heart and spine - areas you want to hit for a sure, quick stop. Hits that create a sure and quick stop tend to also be those that are fatal. I believe the 6 out of 7 people surviving handgun wounds is primarily due to poor marksmanship exemplified by gang violence and "spray and pray" shooting.