I met a cop on medical leave driving a cab. He had been shot with a .22 pistol by a criminal who had just been shot through the heart and both lungs with .00 buck and was still firing. He said the criminal was high on drugs.
It sounds like what rabies does to animals.
I know someone who had to try to take out a rabid raccoon. He emptied his gun into it at pretty close range, and it still didn't stop it.
IIRC, the wife said it was a 357 Magnum.