ICYMI:
https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext
“Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :1-17, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo.
However, this study was performed with the original Wuhan/D614G strain. Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants.
Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains.
This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain.
⚡However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity.
Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors).”⚡
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Excerpt from Ken Denninger:
So here’s what happened.
In mid-December, before the first person had full vaccinated immunity, cases were falling dramatically in the United States.
Herd Immunity.
For real. It was over. We had suffered, but, had we not been stupid, Covid was more-or-less finished with us. Yes, there were and would remain some of us who hadn’t gotten it, and the extremely rare person who could get it a second time, that would continue to get the virus.
It was, however, over.
But we were stupid.
We jabbed a huge percentage of our population. And as has occurred every other time with coronavirus vaccine attempts the virus mutated around the protection and in fact used the vaccine antibodies to enhance infection.
Delta is in fact promoted by those who were vaccinated. As with all other Covid variants most people get a mild or no real illness, but some people get hammered.
However, prior infection doesn’t help if you got jabbed since you took a drug that helps the virus attack you.
We created a third wave by our own stupidity: Stupidity seen in nation after nation, but only in nations with high vaccine prevalence; Israel, the UK, Iceland and here in the United States.
Don’t run the bull**** on me that this isn’t happening: Not only is the science now in on how its happening but Israel and Palestine, two nations literally next door to each with one having near 100% vaccination and the other about 10% could not be more-stark. Palestine is seeing a small uptick in infections while Israel is getting hammered.
The “smartest men in the room” screwed not just a nation — bad enough — but an enormously-large part of the world. Including, quite possibly, you.
There’s a reason we’ve never attempted to vaccinate against coronaviruses before.
THIS IS THE REASON!
