Posted on 08/16/2021 12:31:42 PM PDT by Qiviut
According to studies:
ADE can make vaccinated people more susceptible to serious infection from the virus "ADE may be a concern" for those who have been vaccinated for Covid-19 With ADE, after people get vaccinated for an initial virus, infection by a subsequent variant or strain of the virus can result in "increased viral replication and more severe disease, leading to major safety risks" ADE can also "occur when neutralizing antibodies (which bind the virus and stop it from causing infection) are present at low enough levels that they don't protect against infection. Instead, they can form immune complexes with viral particles, which in turn leads to worse illness" This concern was initially described by some scientists who were subsequently banned from media platforms that incorrectly claimed the scientists were disseminating disinformation Study scientists suggest the answer is to create a new vaccine
In a new study in the Journal of Infection, scientists explain one likely reason why so many vaccinated people are getting sick: a dangerous phenomenon called Antibody Dependent Enhancement or ADE.
Despite the fact that multiple medical authorities predicted, told us, and hoped, ADE would not impact Covid-19 vaccines, data from the study indicates it has done just that.
According to the new study, data suggests that the Covid-19 vaccines originally appeared to provide an overall benefit in fighting the virus. However, when it comes to one of the newer iterations of Covid, the Delta variant, the vaccines appear to facilitate infection displaying "a strikingly increased affinity" for the virus' trademark spike protein.
The scientists conclude that "ADE may be a concern" for those who have been vaccinated for Covid-19.
Read the study here [see live link at source].
According to scientific study, the ADE risk was well known prior to the Covid-19 vaccines being allowed on the market.
"One potential hurdle for antibody-based vaccines and therapeutics is the risk of exacerbating COVID-19 severity via antibody-dependent enhancement (ADE)," explained a study in Nature. "ADE can increase the severity of multiple viral infections, including other respiratory viruses such as respiratory syncytial virus (RSV) and measles."
Scientists say that with ADE, after people get vaccinated for an initial virus, infection by a subsequent variant or strain of the virus can result in "increased viral replication and more severe disease, leading to major safety risks."
"Non-neutralizing antibodies generated by past infection or vaccination fail to shut down the pathogen upon re-exposure. Instead, they act as a gateway by allowing the virus to gain entry and replicate in cells that are usually off limits... That, in turn, can lead to wider dissemination of illness, and over-reactive immune responses that cause more severe illness," according to scientists.
An article in MedPage (prior to the new study) dismissed concerns about ADE, but noted it "can also occur when neutralizing antibodies (which bind the virus and stop it from causing infection) are present at low enough levels that they don't protect against infection. Instead, they can form immune complexes with viral particles, which in turn leads to worse illness."
On the other hand, most scientific studies on this topic say those who have recovered from Covid-19 have natural immunity that does not display the same problem, and appears to be superior to that, so far, of that provided by the vaccines.
Nonetheless, the Centers for Disease Control (CDC) and many public health officials are pressing for more people to get vaccinated, including those who have been previously-infected with Covid. (Numerous studies suggest there is no benefit to recovered patients getting vaccinated.) The health officials state that the vaccinated patients who are getting Covid are getting milder forms than they would have if they had not been vaccinated. However, that is a case-by-case assumption and is impossible to prove.
In Israel, health officials say that only 1% among Covid infections in the latest wave are among those previously infected with Covid. The other 99% are among unvaccinated and not previously-infected, and among fully-vaccinated.
According to the new study, the solution to the current ADE problem is to invent a new, updated version of the vaccine.
Read more from the new study below [at the link]:
And just going through what’s come out since the start of 2021, looks to me like papers aren’t being published on the subject.
If that’s the case, we need to know why.
Or maybe Covid is very contagious. You can still get the Flu after you are vaccinated for it
First link references the 2012 study done in SARS2003.
That study focused on antibodies to the N (nucleocapsid) protein. None of the vaccines target that antigen and none produce antibodies to it. Know what does produce antibodies to the N protein? Infection.
Second link again talks about evidence from SARS2003 studies, along with RSV and Dengue vaccine research.
STILL no evidence anywhere of any ADE in vaccinated or reinfected COVID-19 patients.
Do you read your links before you post them?
I do get those mixed up.
One of the vaxed did receive the monoclonals yesterday. She is doing a bit better, but (her words) feels “like I’m going to die.”.
The rest are feeling like the flu. One was recovered enough he was fishing on the Mississippi. I was a bit annoyed, but he said “I am out here alone and in the sun. Plenty of isolation.”
It can also occur when the antibodies from the vaccines wane.
This is from the FDA EUA document for Pfizer, page 49.
https://www.fda.gov/media/144245/download
Vaccine-enhanced disease
Available data do not indicate a risk of vaccine-enhanced disease, and conversely suggest effectiveness against severe disease within the available follow-up period. However, risk of vaccine-enhanced disease over time, potentially associated with waning immunity, remains unknown and needs to be evaluated further in ongoing clinical trials and in observational studies that could be conducted following authorization and/or licensure.
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