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Delaying a COVID Vaccine’s Second Dose Boosts Immune Response in the Elderly
The Scientific American ^ | May 2021 | Heidi Ledford

Posted on 08/14/2021 4:42:18 PM PDT by CondoleezzaProtege

It is the first direct study of how such a delay affects coronavirus antibody levels, and could inform vaccine scheduling decisions in other countries, the authors say. “This study further supports a growing body of evidence that the approach taken in the UK for delaying that second dose has really paid off,” Gayatri Amirthalingam, an epidemiologist at Public Health England in London and a co-author of the preprint, said during a press briefing.

Many COVID-19 vaccines are given in two doses: the first initiates an immune response, and the second, ‘booster’ shot strengthens it. Clinical trials of the three vaccines used in the United Kingdom generally featured a three- to four-week gap between doses.

But for some existing vaccines, a longer wait between first and second doses yields a stronger immune response. Delaying the COVID-19 booster shots could also expand partial immunity among a greater swathe of the population than could the shorter dosing schedule. On 30 December, the United Kingdom announced that it would delay the second dose by up to 12 weeks after the first.

To determine whether the delay paid off, Amirthalingam and her colleagues studied 175 vaccine recipients older than 80 who received their second dose of the Pfizer vaccine either 3 weeks or 11–12 weeks after the first dose. The team measured recipients’ levels of antibodies against the SARS-CoV-2 spike protein and assessed how immune cells called T cells, which can help to maintain antibody levels over time, responded to vaccination.

Peak antibody levels were 3.5 times higher in those who waited 12 weeks for their booster shot than were those in people who waited only 3 weeks. Peak T-cell response was lower in those with the extended interval. But this did not cause antibody levels to decline more quickly over the nine weeks...

(Excerpt) Read more at scientificamerican.com ...


TOPICS: Health/Medicine
KEYWORDS:
Monica Gandhi MD, MPH
@MonicaGandhi9

"I just realized that maybe re-infection even with mild symptomatic breakthroughs more common in Israel/US than UK/Canada because former opted for 3 weeks between vax doses instead of 12 & then 8 weeks in UK/Canada (longer duration increases antibodies)"

1 posted on 08/14/2021 4:42:18 PM PDT by CondoleezzaProtege
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To: BeauBo; 2aProtectsTheRest; House Atreides; lightman

Ping


2 posted on 08/14/2021 4:42:44 PM PDT by CondoleezzaProtege
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To: CondoleezzaProtege

this GAIN OF FUNCTION Bioweapon was never tested fully
because the animals died, and the techs and their wives
became dysmenorrheic or worse.

THAT made it “safe” for babies, children, pregnant
women, JUST LIKE DES and thallidomide because
profits were INEVITABLE for Biopharma and Congress.


3 posted on 08/14/2021 4:44:43 PM PDT by Diogenesis (Tuitio Fidei et Obsequium Pauperum)
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To: CondoleezzaProtege

There is a woman, a doctor, in the Canadian Health Administration who suggested that Canada delay the 2nd dose to 4 months after the first for this very reason. Some accused her of trying to ration their supply, which may also be true. But she had a logical basis for her recommendation.


4 posted on 08/14/2021 4:44:50 PM PDT by monkeyshine (live and let live is dead)
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To: CondoleezzaProtege

Thank you for the post.


5 posted on 08/14/2021 4:46:56 PM PDT by KC_Lion
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To: CondoleezzaProtege

Let the body do it’s job


6 posted on 08/14/2021 4:47:36 PM PDT by butlerweave
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To: CondoleezzaProtege

One of the variable factors they frequently (usually?) test for in Phase 3 trials of vaccine candidates is partitioning the groups into sub-groups with varying time elapsing between shots to see which is best, I believe they didn’t do that in these vaccine trials to come to a quicker conclusion regarding efficacy versus the placebo group.


7 posted on 08/14/2021 4:48:04 PM PDT by House Atreides
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To: CondoleezzaProtege

Who thinks they are not experimenting on us?

(Not feeling cute like a lab rat. Not running out to get jabbed.)


8 posted on 08/14/2021 4:51:25 PM PDT by EasySt (Say not this is the truth, but so it seems to me to be, as I see this thing I think I see #KAG.)
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To: Diogenesis

The obvious obfuscation, with these dangerous shots, is proof they have no business pushing them.

What....have too many suffered adverse effects, or WORSE, that they’re now going to dial back?

Sickening what we’ve seen mandated/authorized, etc by so called medical experts, in our govt.

All for something with a 99.8% survivable rate. We should be TREATING, not “vax”ing.

And, equally sickening seeing so many who fell for it.

Just heartbreaking.


9 posted on 08/14/2021 4:53:11 PM PDT by Jane Long (America, Bless God....blessed be the Nation.)
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To: monkeyshine

10 posted on 08/14/2021 4:53:45 PM PDT by EasySt (Say not this is the truth, but so it seems to me to be, as I see this thing I think I see #KAG.)
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To: CondoleezzaProtege

Would simply not getting a booster allow for the antibodies to reach their greatest potential without outside interference? Chortle at will, I barely know basic first aid and will not be offended.


11 posted on 08/14/2021 4:55:31 PM PDT by skr (May God confound the enemy)
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To: EasySt

Says it all. 😩


12 posted on 08/14/2021 5:05:35 PM PDT by Jane Long (America, Bless God....blessed be the Nation.)
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To: CondoleezzaProtege

Because of the vaccines we are going to have a thousand variants. Getting more an more deadly.


13 posted on 08/14/2021 5:22:15 PM PDT by Revel
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To: CondoleezzaProtege; All
I understand that if you are in a high risk group for the worst problems after getting infected with CV19 virus, then take the experimental jab.

Otherwise, why not let healthy natural immunity do its job with vitamins C and D3, also zinc, in my non-medical opinion.

Corrections, insights welcome.

14 posted on 08/14/2021 5:56:54 PM PDT by Amendment10
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To: CondoleezzaProtege; lightman

Ping!


15 posted on 08/22/2021 10:13:25 PM PDT by CondoleezzaProtege
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