[HartleyMBaldwin]

Are there nutritional supplements that will increase sphingosine and other sphingolipid levels?

[Arkansas Tider]

Apparently quercetin and capsaicin worked well in a study.

[FlyingFish]

Vitamin D

As for foods to increase sphingosine: eggs, cheese, cream and sweet potatoes. Hmmm, sweet potatoes Au gratin? But don’t eat too much or the BMI will rise, and that’s not a good bio marker for severe Covid.

[Amendment10]

"Conversely, elevated levels of sphingosine, as well as a protein involved in its production, acid ceramidase (AC) [emphases added], are associated with asymptomatic infections."

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"Are there nutritional supplements that will increase sphingosine and other sphingolipid levels?"

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This is way, way out of scope of anything that I've ever studied, but a duckduckgo search seemingly questions vitamin D3 in connection with production of chemicals sphingosine and acid ceramidase.

"In this study, we tested the hypothesis that vitamin D supplementation would alter circulating long-chain ceramides and related metabolites involved in sphingolipid [emphases added] metabolism in humans." -- Vitamin D3 Supplementation Increases Long-Chain Ceramide Levels in Overweight/Obese African Americans: A Post-Hoc Analysis of a Randomized Controlled Trial (4.2.20)

I don't know what the conclusion was.

Corrections, insights welcome.

[redangus]

Based on further reading; eggs, beef, chicken, cheese, butter, cream and soybeans All contain relatively high levels of it. It is also found in the body in LDL and VLDL cholesterol. Studies show it is also an important mediator of colon cancer and atherosclerosis.

[blueplum]

Cows show how important they are once again: Drink your milk!

https://academic.oup.com/jn/article/129/7/1239/4722573