Have unvaccinated folks who previously had covid and were later re-exposed, gotten a worse case/ADE ?
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LL and GW’s replies about ADE left me with some questions, I’ll have to re-read and think.
But I am wondering about Wild’s question, esp in connection with what I’ve read, if a person had covid, it gives them immunity, not a worse case down the road like with dengue.
That’s because of the specific antibodies invovled.
I lost the link but I read that those who had natural covid infections, made more antibodies to the nucleocapsid protein s than to the spike.
It might be (hint: someone should do studies on animal models but the probably can’t get funding and won’t be allowed to publish) that antibodies to nucleocapsid proteins do not lend themselves to ADE, but that antibodies to spike proteins do.
That’s my impression too, lj. Natural infection limits re-infection possibilities, for sure, and likely the severity as well. Dr. Yeadon, former Pfizer VP, believes that any variants/samiants would have to be different by 50% or more for the immune system to not be able to recognize and fight it. That’s the nature of the human immune system, even after years/decades of dormant immunity. This was proven with the initial SARS breakout that started in 2002. Nineteen years later, those infected back then still mounted an immune response when exposed to a SARS virus that was up to 30% genetically different.
That reminds me of something he or another doctor said about human immunity. Doing an antibody test to try to gauge a person’s likely immune response is a poor way to determine their chance of disease if exposed again. He described that the presence of antibodies diminishes over time, like soldiers who have been reassigned or retired. But once the body detects the presence of the pathogen again, the immune “soldiers” immediately come out of retirement and jump-start the antibody defense again.
While there isn’t a high presence of antibodies in the patient forever, they can be quickly multiplied when required in a reasonably healthy individual. His point was that you can’t measure a person’s likelihood for disease from an antibody snapshot when the person hasn’t been re-exposed. This is important because there are ‘experts’ who claim that they tested the antibodies in prior covid and SARS patients and there was a low antibody count. These ‘experts’ claim this proves they’re unprotected and still need the vaccines. Dr. Yeadon refuted that without reservation or qualification, citing the body’s ability to quickly start making antibodies upon re-exposure.