Study shows that anti-parasitic drug slows pancreatic cancer in mice

Medical XPress / Johns Hopkins University School of Medicine / Oncotarget ^ | Aug 3, 2021 | Tara Williamson, et al

[ConservativeMind]

As the third-most lethal cancer in the United States, with only a 1% five-year survival rate for people with its most aggressive form, pancreatic cancer has long been a target of researchers who search for ways to slow or stop its growth and spread. Now, researchers have found that an anti-parasitic drug prevents pancreatic cancer's initiation, progression and metastasis in genetically engineered mice.

…Mebendazole could slow or stop the growth and spread of both early and late-stage pancreatic cancer.

"We think that mebendazole could have a role in all stages," Riggins says. "It was particularly effective for pancreatic cancer that was detected early."

Riggins and his team administered mebendazole to mice that were genetically engineered to develop pancreatic cancer. The team measured the inflammation and the change in tissue, as well as the stage, grade and metastatic status in each tumor.

Tubulin, Riggins explains, is both a micro-skeleton of the inner cell and a highway for transport. The drug gets into the parasite's gut and collapses the tubulin, starving the parasite to death. The study shows that mebendazole may act similarly in pancreatic cancer by collapsing cancer cells' structure, along with other mechanisms such as reducing inflammation.

Riggins says he hopes to continue his team's research through human clinical trials.

"We are advocating for use of mebendazole as a therapy for those diagnosed before metastasis to see if we can slow or prevent pancreatic cancer," Riggins says. "For those with more advanced cancers, it could be an alternative to certain surgeries. Mebendazole may have utility as a therapy after initial treatment to prevent tumor recurrence in the 15% to 20% of pancreatic adenocarcinoma patients who undergo surgery. It may also increase the durability of response to standard chemotherapy in the remaining 80% to 85% of patients with advanced disease."

[Auntie Mame]

Great post.

[Jane Long]

From your/hulda’s link....

Anti-cancer
There is a continuously accumulating body of evidence that ivermectin may have substantial value in the treatment of a variety of cancers. The avermectins are known to possess pronounced antitumor activity,107 as well as the ability to potentiate the antitumor action of vincristine on Ehrlich carcinoma, melanoma B16 and P388 lymphoid leukemia, including the vincristine-resistant strain P388.108

Over the past few years, there have been steadily increasing reports that ivermectin may have varying uses as an anti-cancer agent, as it has been shown to exhibit both anti-cancer and anti-cancer stem cell properties. An in silico chemical genomics approach designed to predict whether any existing drugs might be useful in tackling glioblastoma, lung and breast cancer, indicated that ivermectin may be a useful compound in this respect.109

---

That’s what BigPharma pimps and FRoctors don’t want you to know about ivermectin.

They are downright nasty about the mere mention of it.

[Jane Long]

Sounds like you’ve all had similar reactions/success as the Edmonton OK guy.

I saved his protocol, somewhere.

We keep that on hand.

[MHGinTN]

Bookmarking fenbendazole, etc.