Posted on 08/01/2021 12:59:28 PM PDT by ConservativeMind
A team of researchers has found evidence that suggests giving patients ACE inhibitors reduces the ability of their immune system to fight off bacterial infections. In their paper, the group describes testing of multiple ACE inhibitors in mice and human cells.
ACE inhibitors are drugs that are typically given to patients who have hypertension, and in some cases, to people with heart failure, kidney disease or diabetes. Administration of the drugs relaxes the walls of arteries, veins and capillaries, which in turn reduces blood pressure. Some prior research had shown that the drugs also help the immune system by bolstering the efforts of neutrophils—cells produced to fight bacteria. In this new study, the researchers have found the opposite to be true.
To test the impact of ACE inhibitors on the immune system, the researchers gave test mice different ACE inhibitor brands such as Zestril and Altace, and then tested their ability to ward off bacterial infections. Compared to untreated mice, those with the ACE inhibitors had more difficulty fighting off bacterial infections, such as staph.
Seven human patients who were taking an ACE inhibitor volunteered blood samples to measure their immune response. The researchers found that the neutrophils were unable to produce the molecules needed to fight off bacteria. They were also found to be ineffective when exposed to bacteria in a lab dish.
In related work, the researchers also tested another drug used to treat hypertension, an angiotensin II receptor drug called Cozaar—such drugs work by preventing arterial walls from constricting, which reduces blood pressure. They found no evidence of a negative impact on immunity.
The researchers conclude that patients given ACE inhibitors are at an increased risk of bacterial infections, noting that doctors may want to try other drugs to treat their patients.
(Excerpt) Read more at medicalxpress.com ...
Almost all are available as generics.
Good News & Bad News:
I DuckDuckGo’ed my blood pressure med and it’s an ARB, so that’s good.
The bad news the search showed is that it is made in China. We need to have Trump backtrack repatriate the manufacture of critical drugs!
IIRC, some ACE1 down-regulators may have the side effect of increased ACE2 expression which is not advantageous regarding SARS.
ARBs have always been a better choice that ACEs because ARBs have a MUCH lower side-effect profile than ACEs ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303500/#!po=13.7755
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Immune suppression matters most when the immune system is overreacting to an infection, like with the cytokine storm during influenza.
A good, naturally occurring ACE inhibitor is Vitamin D.
Ping
Experimental studies and clinical trials have shown that angiotensin-II converting enzyme (ACE) inhibitors and angiotensin-II receptor blockers are effective in preventing atrial fibrillation in patients with arterial hypertension or several forms of heart disease.
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