Monkeypox is a rare disease that is caused by infection with monkeypox virus.
Monkeypox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorded in 1970 in the Democratic Republic of the Congo (DRC), and since then the infection has been reported in a number of central and western African countries. Most cases are reported from DRC and Nigeria.
In 2003, monkeypox was recorded in the USA when an outbreak occurred following importation of rodents from Africa. Cases were reported in both humans and pet prairie dogs. All the human infections followed contact with an infected pet and all patients recovered. No other country outside West and Central Africa has reported similar cases or outbreaks.
On 3 December 2019, a patient was diagnosed with monkeypox in England. This is the fourth case diagnosed in the UK since the first imported cases in 2018. Two other cases in travellers were diagnosed in Israel in 2018 and Singapore in 2019.
https://www.gov.uk/guidance/monkeypox
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From 1958 to 1977, the World Health Organization conducted a global vaccination campaign that eradicated smallpox, making it the only human disease to be eradicated. Although routine smallpox vaccination is no longer performed on the general public, the vaccine is still being produced to guard against bioterrorism, biological warfare, and for monkeypox.[2][3]
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1958 might be the key
Well, we have travel from all parts of the world. We now probably host viruses that we do not even know about at the moment.
But after a few hundred years, the virus distribution should be uniform world wide...but what will we humans have become?
I’ll take just about anything rather than a human/clam hybrid.