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To: Robert DeLong

From your link: “Zinc is a decidedly anti-viral mineral. High intracellular concentrations inhibit the replication of RNA type viruses, such as SARS-CoV-2. Zinc does this by blocking RNA-dependent RNA polymerase, the core enzyme of their multiprotein replication and transcription complex that is critical for the copying of viral RNA.”

From my post: “In my mind, HCQ allowed a pathway for the zinc to enter the cell where it interfered with the transcription process.” I didn’t mention the action of the RNA-dependent RNA polymerase, because I wanted to keep it simple. The virus’s RNA being transcripted by the ribosome leaves the ribosome and goes to the RNA-dependent RNA polymerase to synthecize multiple copies of the RNA which uses the polyproteins given off by the ribosome to duplicate multiple copies of the Covid virus. I didn’t think you wanted to read all of that. There is actually more to it than that. It can get boring.

The messenger RNA method has had 50 years of research going into it. According to Robert Langer, the David H. Koch Institute Professor at MIT, a member of the Koch Institute, and one of the founders of Moderna, “With traditional vaccines, you have to do a lot of development. You need a big factory to make the protein, or the virus, and it takes a long time to grow them. The beauty of mRNA is that you don’t need that. If you inject nanoencapsulated mRNA into a person, it goes into the cells, and then the body is your factory. The body takes care of everything else from there.”

Langer has spent decades developing novel ways to deliver medicines, including therapeutic nucleic acids such as RNA and DNA. In the 1970s, he published the first study showing that it was possible to encapsulate nucleic acids, as well as other large molecules, in tiny particles and deliver them into the body. (Work by MIT Institute Professor Phillip Sharp and others on RNA splicing, which also laid groundwork for today’s mRNA vaccines, began in the ’70s as well.)

“It was very controversial at the time,” Langer recalls. “Everybody told us it was impossible, and my first nine grants were rejected. I spent about two years working on it, and I found over 200 ways to get it to not work. But then eventually I did find a way to get it to work.”

That paper, which appeared in Nature in 1976, showed that tiny particles made of synthetic polymers could safely carry and slowly release large molecules such as proteins and nucleic acids. Later, Langer and others showed that when polyethylene glycol (PEG) was added to the surface of nanoparticles, they could last in the body for much longer, instead of being destroyed almost immediately.

In subsequent years, Langer, Anderson, and others have developed fatty molecules called lipid nanoparticles that are also very effective at delivering nucleic acids. These carriers protect RNA from being broken down in the body and help to ferry it through cell membranes. Both the Moderna and Pfizer RNA vaccines are carried by lipid nanoparticles with PEG.

“Messenger RNA is a large hydrophilic molecule. It doesn’t naturally enter cells by itself, and so these vaccines are wrapped up in nanoparticles that facilitate their delivery inside of cells. This allows the RNA to be delivered inside of cells, and then translated into proteins,” Anderson says.

In 2018, the FDA approved the first lipid nanoparticle carrier for RNA, which was developed by Alnylam Pharmaceuticals to deliver a type of RNA called siRNA. Unlike mRNA, siRNA silences its target genes, which can benefit patients by turning off mutated genes that cause disease.

One drawback to mRNA vaccines is that they can break down at high temperatures, which is why the current vaccines are stored at such cold temperatures. Pfizer’s SARS-CoV-2 vaccine has to be stored at -70 degrees Celsius (-94 degrees Fahrenheit), and the Moderna vaccine at -20 C (-4 F). One way to make RNA vaccines more stable, Anderson points out, is to add stabilizers and remove water from the vaccine through a process called lyophilization, which has been shown to allow some mRNA vaccines to be stored in a refrigerator instead of a freezer.

The striking effectiveness of both of these Covid-19 vaccines in phase 3 clinical trials (roughly 95 percent) offers hope that not only will those vaccines help to end the current pandemic, but also that in the future, RNA vaccines may help in the fight against other diseases such as HIV and cancer, Anderson says.

I guess when I tell this factual information, you want to reject it because it does not fit the anti-vaxx narrative. I say get the politics out of the science. Let’s share what we know is true and learn from it.


74 posted on 07/15/2021 11:18:17 AM PDT by jonrick46 ( Leftnicks chase illusions of motherships at the end of the pier.)
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To: jonrick46
I guess when I tell this factual information, you want to reject it because it does not fit the anti-vaxx narrative. I say get the politics out of the science. Let’s share what we know is true and learn from it.

Your first problem, as even pro-vaxxers are turning against these "vaccines", so do not blame it all on anti-vaxxers. There 2nd part of your problem is thinking people who are rejecting these "vaccines are being political in their rejection of these "vaccines".

The reasons people are rejecting these "vaccines are a) don't want to take the chance on being either one of those experiencing life changing adverse reactions, including death, b)they do not wish to participate in an experimental "vaccine" trial, which is what these are, and c) they don't like being compelled to participate against their wishes, which is what this is ultimately becoming, otherwise, they are being threatened to lose their jobs or be subjected to being treated like pariah at the workplace.

The History of the mRNA Vaccines

I have taken the polio virus vaccine, so technically I am not an anti-vaxxer. I just prefer for my immune system to handle viruses.

Another real issue with these mRNA viruses is that they do not stay in the arm injection site like other vaccines, and that one location produces the anti-bodies that then enter the blood stream. The problem is that these mRNA "vaccines" do not stay in the arm injection site, but instead travel through your entire body, even going to the brain.

Perhaps what you need to do is check out the VAERS database to see exactly what the adverse reactions are.

This is from 6/17/2021, so it is quite outdated, and it has gotten much worse (the U.S. is now over 9,000 deaths the last I heard):

Image

There are other considerations within the equation as well:

Introducing the 'Great Reset,' world leaders' radical plan to transform the economy

So it's not all about money, but is also about power grab.

75 posted on 07/15/2021 1:06:11 PM PDT by Robert DeLong
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