As a recovered sufferer of Barrett’s esophagus I am on PPIs for life. They are great, other than the risk of osteoporosis and other conditions that result from lack of ability to digest various minerals. And some suggestion of increased risk or dementia. Other than that, though, really great.
I’ve got Barrett’s esophagus too, and will be on Lansoprazole, for life. I’ll be 74 next month. Nobody else in my family ever had GERD. They were all smokers. I wasn’t. Three died of lung cancer. One of a stroke. And one from heart attack. They were all between the ages of 74 and 51 when they died.