Dr Marschalek suggests that the vaccine is delivered to the nucleus of the cell – a blob of DNA in the middle – rather than to the fluid around it that acts as a protein factory.
Does the doctor not know that the viral vector vaccines are DESIGNED to enter the cell nucleus rather than the cytoplasm only as the less intrusive mRNA vaccines do?
More likely, the author has no business writing a medical piece.
Yeah, I doubt the author of that article understands what is being theorized by the authors of the study.
Basically, what the study proposes is that unlike the mRNA vaccines, the adenovirus vector vaccines go through processes in the nucleus that produce variants of the spike protein. The spike proteins should anchor to the cell membrane of the cells producing them which is what happens with the spike proteins produced by the mRNA vaccines. But with the adenovirus vaccines, some of the spike protein variants lack the means to anchor to the cell membrane and pass into the bloodstream and may attach to endothelial cells causing inflammation that may result in clotting. The likelihood of that happening is greater with AstraZeneca than with J & J, but will occur with both by the mechanism proposed by the authors of the study.
FWIW, an author of the study replied(referencing AstraZeneca) to a question someone asked about long term problems in the comments attached to the study. He stiil thinks it’s a good vaccine.:
George Peterson
commented on 28 May, 2021
Are there any long term harmful effects to your findings? In other words, if a person who receives an adenovirus vaccine does not have a blood clot event, is there any other long term concerns of this spike splicing happening?
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Rolf Marschalek
replied on 28 May, 2021
Based on the present data, I would say no. If the first shot didnt caused any problem, the second will be tolerated as well. Most severe side effects were observed between 4-16 days after first vaccination. Knowing this, it will be much easier to counteract these severe side effects in the future. I still think that this vaccine is a good vaccine, but could be made much better if certain things has been changed.