I think it’s the people that are only receiving a half dose are the ones who need to wear two masks.
Some prisoners were accidentally given what they call an overdose of the Covid vaccine. They say they weren’t ill effects but it was more than the intended dosage
Interestingly, dosage is something explored and and determined during the approval process. These idiots blazed right past that and just got emergency use with it’s lower standards.
How about lower IQ’s for all the experts.
Get the booster first and work backwards.
If you look at your bottle of Advil, it says “adults take two tablets”. Dose is always the same whether you’re a 5’2” 100 lbs woman or a 6’4 250 lbs man. Same for Tylenol, flu shot, NyQuil, and everything else.
A longstanding complaint about pharmaceutical testing is that it traditionally excluded women from test groups entirely. Why? You want consistency with your test group to reduce confounding factors because that simplifies your data. But women have monthly cycles that change hormone levels and introduce all kinds of complication. So the solution - for a very long time - was just to test everything on men. Often, just white men. The assumption was that we’re all human, so it’s close enough.
That’s somewhat changing now and testing on a diverse group is being prioritized more. It increases the cost and complexity of the clinical trials, but everyone immediately understands that it’s crazy to completely ignore half the population and how their bodies might react differently to it. When it comes to dosage on something like a vaccine, it’s unlikely that going with different dosages depending on the size and sex of the person receiving it will have much of an impact. Dosages are determined in pre-clinical trials and adjusted in Phase 1 and sometimes Phase 2 clinical trials.
After that, you test on a large audience in Phase 3 clinical trials to make sure it does what it’s supposed to do. So long as that Phase 3 clinical trial has a diverse population, you’re able to extrapolate that out with good accuracy. It’s not perfect, but there is no perfect without just giving it to everyone to find the edge cases. Phase 3 clinical trials cost an average of $50 million each and about 90% of them fail.
There’s nothing new being done here that isn’t done with every single medicine on the store shelf today. In fact, testing today is far better than it’s been in the past.
Not to sound cliche, but the vaccines will effect everyone differently. I am sure they would effect women a little different than men given physiological and chemical differences inherent in the two different biological sexes. They might even have different effects on different “races” of humans for similar reasons. That’s why FDA wants drug companies to do their utmost to enroll a very diverse population in drug trials.
Beyond the identity question, I do have a number of open questions about the strength of the dose, why it requires 2 doses, why the talk about booster shots etc. I only have a hunch that, given the massive failure that mRNA vaccines have been up to this point, that they actually did make these extremely “low dose” for fear of the types of reactions higher doses would cause... OR ... they know that the immunity doesn’t last very long thus the need for 3 shots a year plus more to come...
It was rushed, and I’m sure if they had more time they could figure out better ways. But they didn’t have time or incentive to take time.
“…As I learned in nursing school, weight is an important factor that is often used to calculate an appropriate dose of medication, and failure to do so may result in various side effects….”
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Do fat people have a stronger and more responsive immune system? Do skinny people have a weaker and less responsive immune system? Not trying to be a smart ass, I really don’t know. I do know (at least I think I know) that all adults (with some exceptions for older people who need a bigger dose because of their weaker immune system) get the same size of vaccine injections regardless of weight.
Zero works great.