Is you is, or is you ain’t, overlooking something?
The spike protein affects for example the ACE2 receptor.
The ACE2 receptor signals the cell to push out a bunch of inflammatory-signaling proteins.
Riddle me this.
On a single SARS-2 COVID19 virion, how many spikes are there?
Because, ya know, a single virion can only itself attach to, merge with (furin cleavage site on the spike protein), and inject RNA into one cell.
So the rest of the spikes on each virion are *wasted*.
But if you inject a truckload of mRNA into cells, and that mRNA tells each cell to turn out a bunch of individual spike protein units, each individual unit can stimulate another cell’s ACE2 receptor: so the effect in terms of host cell lysis/destruction, the mRNA is not as bad as a real infection, but in terms of cell signaling / inflammatory response, it has the potential to be much worse.
The other element I don’t hear people talking about is antibody-dependent enhancement. This is relevant, because back in the days when the coof was isolated in Wuhan, and hadn’t come to the US, people said ADE had been observed in other (IIRC) coronaviruses, I think maybe including SARS-1; and it was posited that ADE was responsible for the “walk down the street and suddenly fall down dead” seen in Wuhan.
You’d have to dig more details, to find things like which sets of viruses exhibit this side effect, and also whether the effect depends more on antibodies to which specific antigens are on the virus’s surface, but I don’t think it can automatically be dismissed by a curt wave of the hand.
” if you inject a truckload of mRNA into cells, and that mRNA tells each cell to turn out a bunch of individual spike protein units, each individual unit can stimulate another cell’s ACE2 receptor: so the effect in terms of host cell lysis/destruction, the mRNA is not as bad as a real infection, but in terms of cell signaling / inflammatory response, it has the potential to be much worse.”
“Potential”... but no evidence of that “potential” occurring.
But do you even care about evidence?
You’ve postulated something- and have no evidence of it occurring- but do you even care?