By what mechanism do you expect those effects to occur?
Unlike Covid-19, the vaccine does not cause cells in multiple tissues to become virus factories, which results in considerable tissue damage. The Pfizer and Moderna vaccines contain mRNA which cells use for a little while to make the antigen and then destroy. The antigen is also destroyed after a short time. The only lasting vaccine effect that I can think of would be the presence of T-cells and B-cells that are trained to attack virus.
There are all kinds of potential issues.
But you’re brushing them under the rug.
https://www.mdpi.com/2076-393X/9/1/36/htm
It is generally thought that the sole function of viral membrane fusion proteins is to allow the viruses to bind to the host cells for the purpose of viral entry into the cells, so that the genetic materials can be released and the viral replication and amplification can take place.
However, recent observations suggest that the SARS-CoV-2 spike protein can by itself trigger cell signaling that can lead to various biological processes. It is reasonable to assume that such events, in some cases, result in the pathogenesis of certain diseases.
Our laboratory only tested the effects of the SARS-CoV-2 spike protein in lung vascular cells and those implicated in the development of PAH. However, this protein may also affect the cells of systemic and coronary vasculatures, eliciting other cardiovascular diseases such as coronary artery disease, systemic hypertension, and stroke. In addition to cardiovascular cells, other cells that express ACE2 have the potential to be affected by the SARS-CoV-2 spike protein, which may cause adverse pathological events.
Thus, it is important to consider the possibility that the SARS-CoV-2 spike protein produced by the new COVID-19 vaccines triggers cell signaling events that promote PAH, other cardiovascular complications, and/or complications in other tissues/organs in certain individuals (Figure 3). We will need to monitor carefully the long-term consequences of COVID-19 vaccines that introduce the spike protein into the human body.
Furthermore, while human data on the possible long-term consequences of spike protein-based COVID-19 vaccines will not be available soon, it is imperative that appropriate experimental animal models are employed as soon as possible to ensure that the SARS-CoV-2 spike protein does not elicit any signs of the pathogenesis of PAH or any other chronic pathological conditions.
No idea. I'm not a biologist, virologist, DNA researcher, etc. Not my fields, I have almost no education in these areas. Heck, I barely passed chemistry in college getting my undergraduate degree.
What I do have is nearly 60 years experience walking this planet, roughly 50 of them doing geeky engineer type stuff.
Three degrees in science and engineering fields.
Three plus decades as an engineer.
An appreciation for human history, in particular as it relates to scientific and engineering adventures.
A cynical attitude developed through long experience with a cynical attitude having been on-target.
An appreciation and deeply held belief in Murphy's law.
But don't worry, I'm not falling into the "appeal to the expert" fallacy. Those points are just there to tell you where I'm coming from.
I also know that mRNA technology has never been used in widespread human trials before.
I know that even the more traditional J&J vaccine was rushed into use faster and more widespread than virtually any other vaccine in history.
I know that one vaccine's initial trial group was 43,000 or so people. An impressive number until you realize that represents just 0.013% of the US population. So we have data on an extremely small percentage (what might be called a rounding error in many engineering endeavors) of the population that we have just barely one year of data on. For most other people, none of these vaccines have ever been tried on someone, anyone with their makeup of DNA, medical history, medications, immune system response, general health, diet, exercise, alcohol use, previous exposure to covid-19 strains or other viruses, etc. Heck, we don't even know (yet) what factors may be important or not. But we're damn-sure going to find out. Some of us have, and are, going to find out the hard way.
I know that even the FDA that approved these vaccines did so only on an emergency basis and as an experimental treatment.
I know we've never before put over a hundred million people into a drug trial before.
So my expectation that we will ultimately be putting tens of thousands of people into early graves, or "merely" into hospitals to receive treatment, or giving them some form of side-effect from the merely annoying to those requiring admission into long term care facilities - is based on our human history of screwing up the first time out of the gate. Statistically, even if our rushed into use, based on new technology vaccines are 99.5% trouble free - which I'm saying in my experience is likely to be wildly optimistic - we're still going to give something like 750,000 people problems of some sort.
I realize I am not in the medical field. Yes, in my experience we screw things up a little or a lot the first time out. I can hear people out there thinking "Yeah, it's one thing to mess up in xyz field, but we have safeguards in fields like aviation and medicine..." Yeah, exactly, and we're currently violating many of those long-developed and blood-soaked safeguards. That is exactly my point.