Fauci: Moderna vaccine 'effective for 6 months'

NHK ^ | 2 hours ago 4/8/21

[2aProtectsTheRest]

"show me documentation that people are not dying of the vaccines."

That isn't how making a claim works. You see, if you make a claim that people are dying because of the vaccines, you have to provide evidence to back up that claim. It doesn't fall on everyone else to prove that your unsubstantiated claim is not true. You may as well claim that aliens built the pyramids and then demand proof that aliens didn't build them. No, the claim is ridiculous and has no available evidence to support it. If you want to convince people, find evidence.

"Miscarriages are up 466%. I think babies are people."

I think babies are people too, and I think your statistics are made up. No source, no link. I have a source for you: the American College of Obstetricians and Gynecologists. And here's a link: Vaccinating Pregnant and Lactating Patients Against COVID-19. And here's where it says you're wrong about miscarriages and COVID-19 vaccines: "As demonstrated below, no differences have been seen when comparing pregnant women participating in the v-safe pregnancy registry with the background rates of adverse pregnancy outcomes."

You see what I did there?

• I stated a clear and simple claim (that miscarriages are not rising in COVID-19 vaccine recipients)
• I provided documentation to that effect from an authoritative source
• I provided a link directly to that source so that you can verify the information I'm providing

[2aProtectsTheRest]

Have any doctors or medical examiners who examined Marvin Hagler’s body contradicted his wife’s assertions? Presumably, she has more access to his medical history and the determination of the doctors working her husband’s case than any random Youtuber or blogger.

So why take their word (which is pure speculation without any access to medical information) over the word of the grieving widow who has access to ALL the medical information on his death?

Why is the wild and unsubstantiated Internet blogger claim more credible than the words of the man’s own wife? Is it because that wild and unsubstantiated blogger claim fits with a narrative you want badly to be true?

[grey_whiskers]

You also left out this gem from your own source.

Vaccines currently available under EUA have not been tested in pregnant women. Therefore, limited safety data specific to use in pregnancy is available. See details about the Food and Drug Administration’s (FDA) EUA process below.

This is the same bullsh*t pollsters do. Play with percentages until they give the numbers you want, while hiding the crosstabs and pretending they don't even exist.

[Cathi]

https://www.mdpi.com/2076-393X/9/1/36/htm

It is generally thought that the sole function of viral membrane fusion proteins is to allow the viruses to bind to the host cells for the purpose of viral entry into the cells, so that the genetic materials can be released and the viral replication and amplification can take place.

However, recent observations suggest that the SARS-CoV-2 spike protein can by itself trigger cell signaling that can lead to various biological processes. It is reasonable to assume that such events, in some cases, result in the pathogenesis of certain diseases.

Our laboratory only tested the effects of the SARS-CoV-2 spike protein in lung vascular cells and those implicated in the development of PAH. However, this protein may also affect the cells of systemic and coronary vasculatures, eliciting other cardiovascular diseases such as coronary artery disease, systemic hypertension, and stroke. In addition to cardiovascular cells, other cells that express ACE2 have the potential to be affected by the SARS-CoV-2 spike protein, which may cause adverse pathological events.

Thus, it is important to consider the possibility that the SARS-CoV-2 spike protein produced by the new COVID-19 vaccines triggers cell signaling events that promote PAH, other cardiovascular complications, and/or complications in other tissues/organs in certain individuals (Figure 3). We will need to monitor carefully the long-term consequences of COVID-19 vaccines that introduce the spike protein into the human body.

Furthermore, while human data on the possible long-term consequences of spike protein-based COVID-19 vaccines will not be available soon, it is imperative that appropriate experimental animal models are employed as soon as possible to ensure that the SARS-CoV-2 spike protein does not elicit any signs of the pathogenesis of PAH or any other chronic pathological conditions.

[SecAmndmt]

“You have a masters in noise? Or signals?”

Both, I am told

[grey_whiskers]

I didn’t have time to read your link, Cathi, so pardon my impertinence.

Is this saying that any interaction with the ACE2 binding site, triggers the innards of the cell to begin other processes, even when the furin cleavage site is not involved (i.e., the virus never even *enters* the cell) ?

If so, this would go a LONG way towards teasing out a putative mechanism for adverse events subsequent to injection with the mRNA.

In particular, the body is not static; a paper out of Harvard I posted a snippet or link from yesterday, pointed out that the body downregulates ACE2 receptors in the uterus during pregnancy, which happily helps protect the growing baby from COVID during early pregnancy.

But if there is such a thing as downregulation, then there may be upregulation. More ACE2 receptors...I vaguely remember papers from before the c00f left China, showing that Chinese males (I think especially smokers) had many more ACE2 binding sites in their lungs than other groups.

Thanks for posting this.

[grey_whiskers]

Might’ve said placenta not uterus. No biggie, as it was only an example of the *kind* of thing I meant.

[Cathi]

The SARS-CoV-2 spike protein, a class I viral fusion protein, is critical to initiating the interactions between the virus and the host cell surface receptor, facilitating viral entry into the host cell by assisting in the fusion of the viral and host cell membranes. This protein consists of two subunits: Subunit 1 (S1) that contains the ACE2 receptor-binding domain (RBD) and Subunit 2 (S2) that plays a role in the fusion process [3,4] (Figure 1). The SARS-CoV-2 spike protein is the major target for the development of COVID-19 vaccines.

While ACE2 is now well known as a ‘receptor’ to which the SARS-CoV-2 spike protein binds on human host cells in order to facilitate the membrane fusion and gain viral entry, the usual physiological function of ACE2 is not to serve as a membrane receptor to transduce intracellular signals. ACE2 is a type I integral membrane protein that functions as a carboxypeptidase, cleaving angiotensin II to angiotensin (1–7) and regulating blood pressure [24,25] (Figure 2).

However, ten years ago, Chen et al. [26] reported the intriguing findings showing that ACE2 acts as a membrane receptor for cell signal transduction in response to the spike protein of SARS-CoV (now also known as SARS-CoV-1, the virus that caused the SARS outbreak in 2002–2004) in the human lung alveolar epithelial cell line, A549. The spike protein of SARS-CoV-1 is 76–78% identical to that of SARS-CoV-2 [27]. In their study, it was shown that the binding of the full-length spike protein to ACE2 triggered the casein kinase II-dependent activation of activator protein-1 (AP-1) transcription factor and subsequent gene transcriptional events [26].

Their finding on SARS-CoV-1 [26] and ours on SARS-CoV-2 [21] indicate that the spike protein remarkably functionally converts ACE2 (that is normally a peptidase enzyme) into a membrane receptor for cell signaling that uses the spike protein as a ligand for its activation

Kuba et al. [28] showed that the injection of mice with recombinant SARS-CoV-1 spike protein reduced the ACE2 expression and worsened the acid-induced lung injury. In mice with an acid-induced lung injury, the recombinant SARS-CoV-1 spike protein dramatically increased angiotensin II, and the angiotensin receptor inhibitor losartan attenuated the spike protein-induced enhancement of lung injury [28].

Thus, these in vivo studies demonstrated that the spike protein of SARS-CoV-1 (without the rest of the virus) reduces the ACE2 expression, increases the level of angiotensin II, and exacerbates the lung injury.

The SARS-CoV-2 spike protein without the rest of the viral components has also been shown to activate cell signaling by Patra et al. [29]. The authors reported that the full-length SARS-CoV-2 spike protein expressed by the means of transient transfection, either in the human lung alveolar epithelial cell line A549 or in the human liver epithelial cell line Huh7.5, activated NF-κB and AP-1 transcription factors as well as p38 and ERK mitogen-activated protein kinases, releasing interleukin-6. This cell signaling cascade was found to be triggered by the SARS-CoV-2 spike protein downregulating the ACE2 protein expression, subsequently activating the angiotensin II type 1 receptor [29]. These experiments using transient transfection may reflect the intracellular effects of the spike protein that could be triggered by the RNA- and viral vector-based vaccines.

These results collectively reinforce the idea that human cells are sensitively affected by the extracellular and/or intracellular spike proteins though the activation of cell signal transduction.

[bagster]

Alright, GW. You just upped the game of BEST RANT EVER.

How high will the bar go?

2a, you're taking a SERIOUS ass whoopin over here. Do you long for the day when it was just memes kicking your ass?

Stay down, son. Stay down.

[bagster]

Why is the wild and unsubstantiated Internet blogger claim more credible than the words of the man’s own wife? Is it because that wild and unsubstantiated blogger claim fits with a narrative you want badly to be true?

As does the wild and speculative words of the man's wife. So, impasse.

Which leads us back to, 'take vax = drop dead'.

At which point, common sense takes over. And you don't have to go to school for that one.

[grey_whiskers]

OK, so what proteins are preferentially (or increasingly) synthesized by the cell upon binding by the spike protein? What are their systemic downstream effects, in those not suffering insult to the lungs by a real c00f infection?

...activated NF-κB and AP-1 transcription factors as well as p38 and ERK mitogen-activated protein kinases,...

Well, The NF-κB transcription factor was discovered 30 years ago and has since emerged as the master regulator of inflammation and immune homeostasis. It achieves this status by means of the large number of important pro- and antiinflammatory factors under its transcriptional control. source

AP-1 Transcription Factors Activator protein 1 (AP-1) is another family of bZIP transcription factors that play a central role in the regulation of neural gene expression by extracellular signals. The AP-1 family comprises multiple proteins that bind as heterodimers (and a few as homodimers) to the DNA sequence TGACTCA.Source

...but!

AP-1 (activating protein-1) is a collective term referring to dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site. As the complexity of our knowledge of AP-1 factors has increased, our understanding of their physiological function has decreased.Source

p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy.Source

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) is a key molecule in intracellular signal transducing pathways that transport extracellular stimuli from cell surface to nuclei.Source

Funny how the molecule chosen for the jab, which they're trying to shame/force on us, hits a cellular receptor which seems to light up the whole freaking immune system in fairly complex, systemic fashion, any time it hits an ACE2 receptor, for which it has affinity.

Next question is, what is the branching ratio for jabs of mRNA (running into a a helpful immune system cell to make antibodies vs. latching onto an ACE2-receptor and playing merry hell with the immune/cellular stress response)?

Are the effects of spike proteins interacting with ACE2 reversible, and is there a typical relaxation time for this to occur?

Is it mediated by the load ACE2 receptors either directly triggered, or cells responding to the proteins and cytokines released by the bound ACE2 receptors?

Anyone honest want to take a stab at this?

[Fury]

Re: 268 - Just one note:

“...and the fact he’s a washed-up computer geek who couldn’t even protect against COMPUTER viruses”

Give an example of ANY OS that protects against COMPUTER viruses to the degree you are suggesting. Hint, not many people use OpenVMS any more (and it got affected by the Morris Worn and WANK). It’s not relevant.

[Georgia Girl 2]

So basically you have no documentation except for CNN and Fox. I see how that werx. 😏

[grey_whiskers]

Not exactly; the, hmmm, "interoperability" (as full of holes as a Swiss Cheese) *philosophy* behind OpenVMS permeated the Gates thinking. He has also long used his own paying customers as beta testers; such contempt goes hand in hand with looking at vulnerabilities as a way to make money selling patches, (and possibly by selling backdoors/zero-day exploits,wink,nudge) to 3-letter agencies, rather than stressing a secure product from the ground up. I appreciate your knowledge to link to openVMS though.

(Good robust boundary and type checking help. I remember an instructor in OBIEE showing us how to hack through the initial screen to get at passwords or root or something of that level of calamity. He ran through it at light speed just to show it, not fast enough that we could follow.)

[grey_whiskers]

Looks like a troll got all butthurt, re: post 283.

[grey_whiskers]

For possible discussion.

I haven't yet read the article, but I noticed the source is a PhD biochemist quoting scientists at Harvard and MIT.

Note, libh8er, that contrary to your assertion earlier (your counterexample from a site that suggested antijabbers had a spurious fear of DNA combining with RNA, a definite strawman), both the commenter and the work he's quoting are people who know the difference...

Could mRNA Vaccines Permanently Alter DNA? Recent Science Suggests They Might.

First sentence from link:

Research on SARS-CoV-2 RNA by scientists at Harvard and MIT has implications for how mRNA vaccines could permanently alter genomic DNA, according to Doug Corrigan, Ph.D., a biochemist-molecular biologist who says more research is needed.... Reverse transcription

[mad_as_he$$]

“a biochemist-molecular biologist who says more research is needed..”

Clearly a “request” for funding. FTM.

[Cathi]

Quite interesting article to me as the controversy between scientists demonstrates once again how unsettled science actually is about this new virus and new vaccines (and pretty much everything else...:-)

First link is to Doug Corrigan’s blog analysis of whether reverse transcription can occur with this virus something that is strongly disputed by other scientists.

https://sciencewithdrdoug.com/2020/11/27/will-an-rna-vaccine-permanently-alter-my-dna/

Next link is to new study that suggests that it may occur.

https://www.biorxiv.org/content/10.1101/2020.12.12.422516v1

“In support of this hypothesis, we found chimeric transcripts consisting of viral fused to cellular sequences in published data sets of SARS-CoV-2 infected cultured cells and primary cells of patients, consistent with the transcription of viral sequences integrated into the genome. To experimentally corroborate the possibility of viral retro-integration, we describe evidence that SARS-CoV-2 RNAs can be reverse transcribed in human cells by reverse transcriptase (RT) from LINE-1 elements or by HIV-1 RT, and that these DNA sequences can be integrated into the cell genome and subsequently be transcribed. Human endogenous LINE-1 expression was induced upon SARS-CoV-2 infection or by cytokine exposure in cultured cells, suggesting a molecular mechanism for SARS-CoV-2 retro-integration in patients. This novel feature of SARS-CoV-2 infection may explain why patients can continue to produce viral RNA after recovery and suggests a new aspect of RNA virus replication.”

This last link is an update by Corrigan who now feels more strongly that this is possible and even probable under certain conditions.

Obviously a lot more study will be necessary to determine the significance (if any) of this.

https://sciencewithdrdoug.com/2021/02/15/breaking-study-sheds-more-light-on-whether-an-rna-vaccine-can-permanently-alter-dna/

[metmom]

Thanks for the ping.

Anyone who’s been around the block knows that science is never settled. Scientists make their pronouncements based on their current understanding of things and that changes by the day. It’s never settled, especially considering how little we actually know about the physical world we inhabit.