The B5 curse is real, 45-60 is the average age the main characters have been dying.
Well, yes, Babylon is cursed by God.
Revelation 17:5 And upon her forehead was a name written, MYSTERY, BABYLON THE GREAT, THE MOTHER OF HARLOTS AND ABOMINATIONS OF THE EARTH.
See also Rev 18:2, 18:10, and 18:21. Babylon is mentioned 286 times in the Authorized Version of the Bible.
Revelation 18:21 And a mighty angel took up a stone like a great millstone, and cast it into the sea, saying, Thus with violence shall that great city Babylon be thrown down, and shall be found no more at all.
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The site of the original city of Babylon is in Iraq, and was destroyed in biblical times. The Bible says it will not be rebuilt. Saddam Hussein tried to rebuild it. Remember what happened to him.